Engaging neuroscience to advance translational research in brain barrier biology

Edward A. Neuwelt; Björn Bauer; Christoph Fahlke; Gert Fricker; Constantino Iadecola; Damir Janigro; Luc Leybaert; Zoltán Molnár; Martha E. O'Donnell; John T. Povlishock; Norman R. Saunders; Frank Sharp; Danica Stanimirovic; Ryan J. Watts; Lester R. Drewes

doi:10.1038/nrn2995

Engaging neuroscience to advance translational research in brain barrier biology

Edward A. Neuwelt
, Björn Bauer
, Christoph Fahlke
, Gert Fricker
, Constantino Iadecola
, Damir Janigro
, Luc Leybaert
, Zoltán Molnár
, Martha E. O'Donnell
, John T. Povlishock
, Norman R. Saunders
, Frank Sharp
, Danica Stanimirovic
, Ryan J. Watts
, Lester R. Drewes

Pharmaceutical Sciences

Producción científica: Review article › revisión exhaustiva

523 Citas (Scopus)

Resumen

The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.

Idioma original	English
Páginas (desde-hasta)	169-182
Número de páginas	14
Publicación	Nature Reviews Neuroscience
Volumen	12
N.º	3
DOI	https://doi.org/10.1038/nrn2995
Estado	Published - mar 2011

Nota bibliográfica

Funding Information:
The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O’Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.

Financiación

The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O’Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.

Financiadores	Número del financiador
National Institutes of Health (NIH)	5 R13 CA086959-10
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	R01NS039953

ASJC Scopus subject areas

General Neuroscience

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10.1038/nrn2995

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Neuwelt, E. A., Bauer, B., Fahlke, C., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O'Donnell, M. E., Povlishock, J. T., Saunders, N. R., Sharp, F., Stanimirovic, D., Watts, R. J., & Drewes, L. R. (2011). Engaging neuroscience to advance translational research in brain barrier biology. Nature Reviews Neuroscience, 12(3), 169-182. https://doi.org/10.1038/nrn2995

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title = "Engaging neuroscience to advance translational research in brain barrier biology",

abstract = "The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier. Recent studies have shown numerous additional roles of these barriers, including an involvement in neurodevelopment, in the control of cerebral blood flow, and - when barrier integrity is impaired - in the pathology of many common CNS disorders such as Alzheimer's disease, Parkinson's disease and stroke.",

author = "Neuwelt, \{Edward A.\} and Bj{\"o}rn Bauer and Christoph Fahlke and Gert Fricker and Constantino Iadecola and Damir Janigro and Luc Leybaert and Zolt{\'a}n Moln{\'a}r and O'Donnell, \{Martha E.\} and Povlishock, \{John T.\} and Saunders, \{Norman R.\} and Frank Sharp and Danica Stanimirovic and Watts, \{Ryan J.\} and Drewes, \{Lester R.\}",

note = "Funding Information: The meeting on which this report was based was partially funded by an R13 grant from the US National Institutes of Health (Grant 5 R13 CA086959-10). We would like to thank all of the people who attended the Engaging Neuroscience to Advance Brain Barriers Translational Research meeting (March 19–21, 2009), Gleneden Beach, Oregon, USA. Special thanks to Lester Drewes, Martha O{\textquoteright}Donnell, Leslie Muldoon and Aliana Kim who were instrumental in the development of this report.",

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Neuwelt, EA, Bauer, B, Fahlke, C, Fricker, G, Iadecola, C, Janigro, D, Leybaert, L, Molnár, Z, O'Donnell, ME, Povlishock, JT, Saunders, NR, Sharp, F, Stanimirovic, D, Watts, RJ & Drewes, LR 2011, 'Engaging neuroscience to advance translational research in brain barrier biology', Nature Reviews Neuroscience, vol. 12, n.º 3, pp. 169-182. https://doi.org/10.1038/nrn2995

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AU - Janigro, Damir

AU - Leybaert, Luc

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AU - Saunders, Norman R.

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AU - Stanimirovic, Danica

AU - Watts, Ryan J.

AU - Drewes, Lester R.

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Engaging neuroscience to advance translational research in brain barrier biology

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ASJC Scopus subject areas

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