Enhancing the divergent activities of betulinic acid via neoglycosylation

Randal D. Goff; Jon S. Thorson

doi:10.1021/ol8025704

Enhancing the divergent activities of betulinic acid via neoglycosylation

Randal D. Goff
, Jon S. Thorson

Producción científica: Article › revisión exhaustiva

41 Citas (Scopus)

Resumen

(Chemical Equation Presented) Using neoglycosylation, the impact of differential glycosylation upon the divergent anticancer and anti-HIV properties of the triterpenoid betulinic acid (BA) was examined. Each member from a library of 37 differentially glycosylated BA variants was tested for anticancer and anti-HIV activities. Enhanced analogs for both desired activities were discovered with the corresponding antitumor or antiviral enhancements diverging, on the basis of the appended sugar, into two distinct compound subsets.

Idioma original	English
Páginas (desde-hasta)	461-464
Número de páginas	4
Publicación	Organic Letters
Volumen	11
N.º	2
DOI	https://doi.org/10.1021/ol8025704
Estado	Published - ene 15 2009

Financiación

Financiadores	Número del financiador
National Institute of Allergy and Infectious Diseases	R37AI052218

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol8025704

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Enhancing the divergent activities of betulinic acid via neoglycosylation

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