Enzymatic tools for engineering natural product glycosylation

Sophie Blanchard; Jon S. Thorson

doi:10.1016/j.cbpa.2006.04.001

Enzymatic tools for engineering natural product glycosylation

Sophie Blanchard
, Jon S. Thorson

Producción científica: Review article › revisión exhaustiva

148 Citas (Scopus)

Resumen

Glycosylated natural products have served as reliable platforms for the development of many existing front-line drugs. In an effort to explore the contribution of the sugar constituents of these compounds, research groups have focused upon the development of chemical and enzymatic tools to diversify natural product glycosylation. Among the complementary routes available, in vivo pathway engineering, also referred to as 'combinatorial biosynthesis', is an emerging method that relies upon the co-expression of sugar biosynthetic gene cassettes and glycosyltransferases in a host organism to generate novel glycosylated natural products. An overview of recent progress in combinatorial biosynthesis is highlighted in this review, emphasizing the elucidation of nucleotide-sugar biosynthetic pathways and recent developments on glycosyltransferases.

Idioma original	English
Páginas (desde-hasta)	263-271
Número de páginas	9
Publicación	Current Opinion in Chemical Biology
Volumen	10
N.º	3
DOI	https://doi.org/10.1016/j.cbpa.2006.04.001
Estado	Published - jun 2006

Nota bibliográfica

Funding Information:
This contribution was supported in part by the National Institute of Health grants AI52218, CA84374 and GM70637, and a National Cooperative Drug Discovery Group Grant U19 CA113297 from the National Cancer Institute. JST is a HI Romnes fellow. The authors thank JM Langenhan for helpful discussions.

Financiación

This contribution was supported in part by the National Institute of Health grants AI52218, CA84374 and GM70637, and a National Cooperative Drug Discovery Group Grant U19 CA113297 from the National Cancer Institute. JST is a HI Romnes fellow. The authors thank JM Langenhan for helpful discussions.

Financiadores	Número del financiador
National Institutes of Health (NIH)	GM70637, U19 CA113297, AI52218
National Childhood Cancer Registry – National Cancer Institute	R01CA084374

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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title = "Enzymatic tools for engineering natural product glycosylation",

abstract = "Glycosylated natural products have served as reliable platforms for the development of many existing front-line drugs. In an effort to explore the contribution of the sugar constituents of these compounds, research groups have focused upon the development of chemical and enzymatic tools to diversify natural product glycosylation. Among the complementary routes available, in vivo pathway engineering, also referred to as 'combinatorial biosynthesis', is an emerging method that relies upon the co-expression of sugar biosynthetic gene cassettes and glycosyltransferases in a host organism to generate novel glycosylated natural products. An overview of recent progress in combinatorial biosynthesis is highlighted in this review, emphasizing the elucidation of nucleotide-sugar biosynthetic pathways and recent developments on glycosyltransferases.",

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note = "Funding Information: This contribution was supported in part by the National Institute of Health grants AI52218, CA84374 and GM70637, and a National Cooperative Drug Discovery Group Grant U19 CA113297 from the National Cancer Institute. JST is a HI Romnes fellow. The authors thank JM Langenhan for helpful discussions.",

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N2 - Glycosylated natural products have served as reliable platforms for the development of many existing front-line drugs. In an effort to explore the contribution of the sugar constituents of these compounds, research groups have focused upon the development of chemical and enzymatic tools to diversify natural product glycosylation. Among the complementary routes available, in vivo pathway engineering, also referred to as 'combinatorial biosynthesis', is an emerging method that relies upon the co-expression of sugar biosynthetic gene cassettes and glycosyltransferases in a host organism to generate novel glycosylated natural products. An overview of recent progress in combinatorial biosynthesis is highlighted in this review, emphasizing the elucidation of nucleotide-sugar biosynthetic pathways and recent developments on glycosyltransferases.

AB - Glycosylated natural products have served as reliable platforms for the development of many existing front-line drugs. In an effort to explore the contribution of the sugar constituents of these compounds, research groups have focused upon the development of chemical and enzymatic tools to diversify natural product glycosylation. Among the complementary routes available, in vivo pathway engineering, also referred to as 'combinatorial biosynthesis', is an emerging method that relies upon the co-expression of sugar biosynthetic gene cassettes and glycosyltransferases in a host organism to generate novel glycosylated natural products. An overview of recent progress in combinatorial biosynthesis is highlighted in this review, emphasizing the elucidation of nucleotide-sugar biosynthetic pathways and recent developments on glycosyltransferases.

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Enzymatic tools for engineering natural product glycosylation

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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