Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise; D. B. Dubal; M. E. Wilson; S. W. Rau

doi:10.1023/A:1007169408561

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

P. M. Wise
, D. B. Dubal
, M. E. Wilson
, S. W. Rau

Producción científica: Article › revisión exhaustiva

71 Citas (Scopus)

Resumen

Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

Idioma original	English
Páginas (desde-hasta)	401-410
Número de páginas	10
Publicación	Journal of Neurocytology
Volumen	29
N.º	5-6
DOI	https://doi.org/10.1023/A:1007169408561
Estado	Published - 2000

Nota bibliográfica

Funding Information:
Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

Financiación

Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

Financiadores	Número del financiador
DBD
Glenn Foundation/American Federation for Aging Research
National Institutes of Health (NIH)	AG00242, AG02224
National Institute on Aging	F32AG005818
University of Kentucky

ASJC Scopus subject areas

Anatomy
General Neuroscience
Histology
Cell Biology

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abstract = "Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.",

author = "Wise, \{P. M.\} and Dubal, \{D. B.\} and Wilson, \{M. E.\} and Rau, \{S. W.\}",

note = "Funding Information: Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice Chancellor{\~O}s Research Funds (PMW).",

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AU - Dubal, D. B.

AU - Wilson, M. E.

AU - Rau, S. W.

N1 - Funding Information: Supported by the National Institutes of Health AG02224 (PMW), AG00242 (PMW), AG05818 (MEW), and the Glenn Foundation/American Federation for Aging Research (DBD) and University of Kentucky Vice ChancellorÕs Research Funds (PMW).

PY - 2000

Y1 - 2000

N2 - Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

AB - Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.

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IS - 5-6

ER -

Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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