Evaluation of High-dose Daptomycin in Children With Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

Katie B. Olney; Manjunath P. Pai; Laura P. Stadler; David S. Burgess

doi:10.1097/INF.0000000000004871

Evaluation of High-dose Daptomycin in Children With Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

Katie B. Olney
, Manjunath P. Pai
, Laura P. Stadler
, David S. Burgess

Pharmacy Practice and Science

Producción científica: Article › revisión exhaustiva

Resumen

Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368–413] in 4 children despite use of high doses (17–20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.

Idioma original	English
Páginas (desde-hasta)	962-964
Número de páginas	3
Publicación	Pediatric Infectious Disease Journal
Volumen	44
N.º	10
DOI	https://doi.org/10.1097/INF.0000000000004871
Estado	Published - oct 2025

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Publisher Copyright:
© 2025

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0000000000004871

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abstract = "Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368–413] in 4 children despite use of high doses (17–20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.",

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AB - Daptomycin dosing in pediatrics has not been updated since initial approval to align with contemporary adult dosing recommendations. We observed lower than anticipated exposures with median 24-hour area under the curve of 378 mg·h/L [interquartile range (IQR): 368–413] in 4 children despite use of high doses (17–20 mg/kg/d). There is a critical need to reappraise daptomycin dosing in pediatric patients for Staphylococcus aureus bloodstream infections.

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KW - pediatrics

KW - pharmacodynamics

KW - pharmacokinetics

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Evaluation of High-dose Daptomycin in Children With Methicillin-resistant Staphylococcus aureus Bacteremia: A Case Series

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