Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence

Warren K. Bickel, David P. Jarmolowicz, E. Terry Mueller, Mikhail N. Koffarnus, Kirstin M. Gatchalian

Producción científica: Review articlerevisión exhaustiva

470 Citas (Scopus)

Resumen

Delay discounting describes the devaluation of a reinforcer as a function of the delay until its receipt. Although all people discount delayed reinforcers, one consistent finding is that substance-dependent individuals tend to discount delayed reinforcers more rapidly than do healthy controls. Moreover, these higher-than-normal discounting rates have been observed in individuals with other behavioral maladies such as pathological gambling, poor health behavior, and overeating. This suggests that high rates of delay discounting may be a trans-disease process (i.e., a process that occurs across a range of disorders, making findings from one disorder relevant to other disorders). In this paper, we argue that delay discounting is a trans-disease process, undergirded by an imbalance between two competing neurobehavioral decision systems. Implications for our understanding of, and treatment for, this trans-disease process are discussed.

Idioma originalEnglish
Páginas (desde-hasta)287-297
Número de páginas11
PublicaciónPharmacology and Therapeutics
Volumen134
N.º3
DOI
EstadoPublished - jun 2012

Nota bibliográfica

Funding Information:
This work was supported by NIDA grants R01DA030241 ; R01DA024080 ; R01DA012997 ; and [NIAAA] R01DA024080-02S1 . The authors would like to thank Patsy Marshall for her assistance in manuscript preparation.

Financiación

This work was supported by NIDA grants R01DA030241 ; R01DA024080 ; R01DA012997 ; and [NIAAA] R01DA024080-02S1 . The authors would like to thank Patsy Marshall for her assistance in manuscript preparation.

FinanciadoresNúmero del financiador
National Institute on Drug AbuseR01DA024080, R01DA030241, R01DA012997, T32DA022981
National Institute on Alcohol Abuse and Alcoholism

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

    Huella

    Profundice en los temas de investigación de 'Excessive discounting of delayed reinforcers as a trans-disease process contributing to addiction and other disease-related vulnerabilities: Emerging evidence'. En conjunto forman una huella única.

    Citar esto