Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Kaitlin Voigts Key; Steven Estus; Terry Lennie; Ana Maria Linares; Gia Mudd-Martin

doi:10.1016/j.hrtlng.2022.04.012

Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Producción científica: Article › revisión exhaustiva

4 Citas (Scopus)

Resumen

Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

Idioma original	English
Páginas (desde-hasta)	77-81
Número de páginas	5
Publicación	Heart and Lung
Volumen	55
DOI	https://doi.org/10.1016/j.hrtlng.2022.04.012
Estado	Published - sept 1 2022

Nota bibliográfica

Funding Information:
This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award.

Publisher Copyright:
© 2022 Elsevier Inc.

Financiación

This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award.

Financiadores	Número del financiador
National Institutes of Health/National Institute of Nursing Research
Office of Behavioral and Social Science	1R01NR016262
University of Kentucky College of Nursing
National Institutes of Health (NIH)
National Center for Research Resources
National Center for Advancing Translational Sciences (NCATS)	UL1TR001998
Center for Clinical and Translational Science, University of Illinois at Chicago

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

Acceder al documento

10.1016/j.hrtlng.2022.04.012

Otros archivos y enlaces

Citar esto

@article{948bf6499af24d708d719342770ef970,

title = "Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease",

abstract = "Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2\%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.",

keywords = "COMT, Cardiovascular disease, Depression, Discrimination, Latinx",

author = "Key, \{Kaitlin Voigts\} and Steven Estus and Terry Lennie and Linares, \{Ana Maria\} and Gia Mudd-Martin",

note = "Funding Information: This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = sep,

day = "1",

doi = "10.1016/j.hrtlng.2022.04.012",

language = "English",

volume = "55",

pages = "77--81",

}

TY - JOUR

T1 - Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

AU - Key, Kaitlin Voigts

AU - Estus, Steven

AU - Lennie, Terry

AU - Linares, Ana Maria

AU - Mudd-Martin, Gia

N1 - Funding Information: This work was supported by the NIH/National Institutes of Nursing and the Office of Behavioral and Social Science [Research Grant 1R01NR016262]; DREAM Scholars Predoctoral Fellowship Program, University of Kentucky College of Nursing and the Center for Clinical and Translational Science, National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health [Grant UL1TR001998]; The University of Kentucky College of Nursing Dissertation Award. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

AB - Background: Ethnic discrimination is frequently experienced among U.S. Latinx communities, and is linked to CVD risk factors, such as depression. Genetic variants may influence this relationship. Objectives: The objectives of this study were to examine associations between experiences of discrimination, rs4680 genotype, and depressive symptoms in Latinx adults. Methods: We analyzed data from 124 Latinx adults with two or more CVD risk factors, and conducted hierarchical linear regression, adjusting for sex, age, income, education, and acculturation. Results: Participants were predominately female (74.2%) and aged 40.2 ± 9.3 years. More experiences of discrimination were associated with higher depressive symptoms (p = 0.041). Those with Met-Met-and Val-Met-genotypes had increased depressive symptoms than those with Val-Val-genotype (p = 0.049). Rs4680 was not a moderator. Conclusion: Findings suggest discrimination and rs4680 genotype are associated with depressive symptoms in Latinx adults, which may increase CVD risk. Further research is needed to better understand biological mechanisms of these relationships.

KW - COMT

KW - Cardiovascular disease

KW - Depression

KW - Discrimination

KW - Latinx

UR - https://www.scopus.com/pages/publications/85129315299

UR - https://www.scopus.com/pages/publications/85129315299#tab=citedBy

U2 - 10.1016/j.hrtlng.2022.04.012

DO - 10.1016/j.hrtlng.2022.04.012

M3 - Article

C2 - 35490661

AN - SCOPUS:85129315299

SN - 0147-9563

VL - 55

SP - 77

EP - 81

JO - Heart and Lung

JF - Heart and Lung

ER -

Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto