Exploring cancer metabolism using Stable isotope-resolved metabolomics (SIRM)

Ronald C. Bruntz; Andrew N. Lane; Richard M. Higashi; Teresa W.M. Fan

doi:10.1074/jbc.R117.776054

Exploring cancer metabolism using Stable isotope-resolved metabolomics (SIRM)

Producción científica: Review article › revisión exhaustiva

91 Citas (Scopus)

Resumen

Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMRand mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

Idioma original	English
Páginas (desde-hasta)	11601-11609
Número de páginas	9
Publicación	Journal of Biological Chemistry
Volumen	292
N.º	28
DOI	https://doi.org/10.1074/jbc.R117.776054
Estado	Published - jul 14 2017

Nota bibliográfica

Funding Information:
This work was supported in part by National Institutes of Health Grants T32CA165990 (to R. C. B.), 1R01ES022191-01 (to T. W. M. F. and R. M. H.), and 1P01CA163223-01A1 (to A. N. L. and T. W. M. F.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiación

This work was supported in part by National Institutes of Health Grants T32CA165990 (to R. C. B.), 1R01ES022191-01 (to T. W. M. F. and R. M. H.), and 1P01CA163223-01A1 (to A. N. L. and T. W. M. F.). The authors declare that they have no conflicts of interest with the contents of this article. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)	1R01ES022191-01, 1P01CA163223-01A1
National Childhood Cancer Registry – National Cancer Institute	T32CA165990

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.R117.776054

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abstract = "Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMRand mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.",

author = "Bruntz, \{Ronald C.\} and Lane, \{Andrew N.\} and Higashi, \{Richard M.\} and Fan, \{Teresa W.M.\}",

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N2 - Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMRand mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

AB - Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMRand mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.

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Exploring cancer metabolism using Stable isotope-resolved metabolomics (SIRM)

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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