Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Zhangkai Jason Cheng; Mingshan Xue; Peiyan Zheng; Jiali Lyu; Zhiqing Zhan; Haisheng Hu; Yong Zhang; Xiaohua Douglas Zhang; Baoqing Sun

doi:10.3390/vaccines9080869

Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Zhangkai Jason Cheng, Mingshan Xue, Peiyan Zheng, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua Douglas Zhang, Baoqing Sun

Producción científica: Review article › revisión exhaustiva

18 Citas (Scopus)

Resumen

Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

Idioma original	English
Número de artículo	869
Publicación	Vaccines
Volumen	9
N.º	8
DOI	https://doi.org/10.3390/vaccines9080869
Estado	Published - ago 2021

Nota bibliográfica

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Financiación

Funding: This project was supported by the Guangzhou Institute of Respiratory Health Open Project (Funds provided by China Evergrande Group) (Project No: 2020GIRHHMS04), and the Zhongnanshan Medical Foundation of Guangdong Province (Project No: ZNSA-2021005 and Project No: ZNSA-2020001).

Financiadores	Número del financiador
China Evergrande Group	2020GIRHHMS04
Guangzhou Institute of Respiratory
Zhongnanshan Medical Foundation of Guangdong Province	ZNSA-2021005, ZNSA-2020001

ASJC Scopus subject areas

Immunology
Pharmacology
Drug Discovery
Infectious Diseases
Pharmacology (medical)

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abstract = "Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines{\textquoteright} shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.",

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AU - Lyu, Jiali

AU - Zhan, Zhiqing

AU - Hu, Haisheng

AU - Zhang, Yong

AU - Zhang, Xiaohua Douglas

AU - Sun, Baoqing

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

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N2 - Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

AB - Vaccines are a crucial part of the global anti-pandemic effort against COVID-19. The effects of vaccines, as well as their common influencing factors, are the most important issues that we should focus on at this time. To this end, we review statistics on immunogenicity after vaccination, using neutralizing antibodies as the main reference index. Age, infection history, and virus variants are compared, and vaccination program recommendations are made accordingly. Suggestions are made to address concerns raised by the vaccines’ shortened development cycle, as well as the emergence of immunity escape of viral variants. Finally, a brief description and future prospects are provided based on the principle of the ADE effect and previous experience with similar viruses.

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Factors affecting the antibody immunogenicity of vaccines against sars-cov-2: A focused review

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

ODS de las Naciones Unidas

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