Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis

Hélvis E.S. Paz; Mabelle F. Monteiro; Camila S. Stolf; Cássia F. Araújo; Angelika Silbereisen; Mauro P. Santamaria; Nagihan Bostanci; Renato C.V. Casarin

doi:10.1111/jcpe.70047

Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis

Hélvis E.S. Paz
, Mabelle F. Monteiro
, Camila S. Stolf
, Cássia F. Araújo
, Angelika Silbereisen
, Mauro P. Santamaria
, Nagihan Bostanci
, Renato C.V. Casarin

Producción científica: Article › revisión exhaustiva

Resumen

Aim: To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods: Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN-γ, IL-10, IL-17, IL-1β, IL-4, TNF-α) and urinary intestinal permeability markers (claudin-2, -3, -4, haptoglobin) were quantified. Results: Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin-2 levels were elevated in both PP and CP groups (p < 0.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes/Bacteroidetes ratio. Conclusions: Parental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral–gut microbial transmission and its relevance to systemic health, warranting further investigation.

Idioma original	English
Páginas (desde-hasta)	222-231
Número de páginas	10
Publicación	Journal of Clinical Periodontology
Volumen	53
N.º	2
DOI	https://doi.org/10.1111/jcpe.70047
Estado	Published - feb 2026

Nota bibliográfica

Publisher Copyright:
© 2025 The Author(s). Journal of Clinical Periodontology published by John Wiley & Sons Ltd.

Financiación

We would like to thank all study participants who volunteered for this study. The Article Processing Charge for the publication of this research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ‐ Brasil (CAPES) (ROR identifier: 00x0ma614). Funding: This work was supported by the São Paulo Research Foundation (FAPESP) [2019/09740-3], [2019/08953-3], and the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES)—Finance Code 001. We would like to thank all study participants who volunteered for this study. The Article Processing Charge for the publication of this research was funded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) (ROR identifier: 00x0ma614). This work was supported by the São Paulo Research Foundation (FAPESP) [2019/09740‐3], [2019/08953‐3], and the Brazilian Coordination for the Improvement of Higher Education Personnel (CAPES)—Finance Code 001. Funding:

Financiadores	Número del financiador
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior	00x0ma614
Fundação de Amparo à Pesquisa do Estado de São Paulo	2019/09740-3, 2019/08953‐3

ASJC Scopus subject areas

Periodontics

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10.1111/jcpe.70047

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title = "Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis",

abstract = "Aim: To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods: Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN-γ, IL-10, IL-17, IL-1β, IL-4, TNF-α) and urinary intestinal permeability markers (claudin-2, -3, -4, haptoglobin) were quantified. Results: Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin-2 levels were elevated in both PP and CP groups (p < 0.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes/Bacteroidetes ratio. Conclusions: Parental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral–gut microbial transmission and its relevance to systemic health, warranting further investigation.",

keywords = "gut microbiome, oral microbiome, parent–child relations, periodontitis, saliva",

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note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). Journal of Clinical Periodontology published by John Wiley \& Sons Ltd.",

year = "2026",

month = feb,

doi = "10.1111/jcpe.70047",

language = "English",

volume = "53",

pages = "222--231",

number = "2",

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AU - Paz, Hélvis E.S.

AU - Monteiro, Mabelle F.

AU - Stolf, Camila S.

AU - Araújo, Cássia F.

AU - Silbereisen, Angelika

AU - Santamaria, Mauro P.

AU - Bostanci, Nagihan

AU - Casarin, Renato C.V.

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N2 - Aim: To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods: Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN-γ, IL-10, IL-17, IL-1β, IL-4, TNF-α) and urinary intestinal permeability markers (claudin-2, -3, -4, haptoglobin) were quantified. Results: Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin-2 levels were elevated in both PP and CP groups (p < 0.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes/Bacteroidetes ratio. Conclusions: Parental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral–gut microbial transmission and its relevance to systemic health, warranting further investigation.

AB - Aim: To investigate whether periodontitis in parents is associated with differences in the faecal microbiome and systemic markers in both themselves and their children. Methods: Eighty participants were divided into four groups (n = 20): parents with periodontitis (PP); healthy parents (PC); and their respective children (CP, CC). Clinical periodontal parameters were recorded. Saliva and faecal bacterial DNA were analysed via 16S rRNA sequencing. Salivary lactoferrin, faecal calprotectin, gingival crevicular fluid cytokines (IFN-γ, IL-10, IL-17, IL-1β, IL-4, TNF-α) and urinary intestinal permeability markers (claudin-2, -3, -4, haptoglobin) were quantified. Results: Parents with periodontitis showed distinct faecal microbiota profiles, which were mirrored in their children and significantly differed from controls. Claudin-2 levels were elevated in both PP and CP groups (p < 0.05) and positively correlated with the oral dysbiosis index and the faecal Firmicutes/Bacteroidetes ratio. Conclusions: Parental periodontal health appears to influence the faecal microbiome and systemic markers in the offspring. These findings highlight a potential pathway for oral–gut microbial transmission and its relevance to systemic health, warranting further investigation.

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KW - oral microbiome

KW - parent–child relations

KW - periodontitis

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Familial Patterns of Oral–Gut Dysbiosis and Systemic Markers in Periodontitis

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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