Filovirus pathogenesis and immune evasion: Insights from Ebola virus and Marburg virus

Ilhem Messaoudi; Gaya K. Amarasinghe; Christopher F. Basler

doi:10.1038/nrmicro3524

Filovirus pathogenesis and immune evasion: Insights from Ebola virus and Marburg virus

Ilhem Messaoudi
, Gaya K. Amarasinghe
, Christopher F. Basler

Producción científica: Review article › revisión exhaustiva

224 Citas (Scopus)

Resumen

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.

Idioma original	English
Páginas (desde-hasta)	663-676
Número de páginas	14
Publicación	Nature Reviews Microbiology
Volumen	13
N.º	11
DOI	https://doi.org/10.1038/nrmicro3524
Estado	Published - nov 1 2015

Financiación

The authors thank C. Schwall for critical reading of this manuscript. The authors were supported by US National Institutes of Health (NIH) grants U19 AI109945 to C.F.B. (Basler-PI), I.M. and G.K.A.; R01 AI059536 and U19 AI109664 to C.F.B.; and U19 AI070489 (Holtzman-PI) and R01 AI081914 to G.K.A. The authors are also supported by the US Department of Defense and the Defense Threat Reduction Agency grants HDTRA1-12-1-0051 and HDTRA1-14-1-0013 to C.F.B. and G.K.A. The content of this Review does not necessarily reflect the position or the policy of the federal government, and no official endorsement should be inferred.

Financiadores	Número del financiador
US Department of Defense
National Institutes of Health (NIH)	U19AI070489, U19AI109664, R01AI081914, R01 AI059536
National Institute of Allergy and Infectious F32-AI286447 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI168214 Jason W. Rosch Diseases National Institute of Allergy and Infectious P30 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R00-AI166116 Christopher D. Radka Diseases National Institute of Allergy and Infectious T32-AI106700 Cydney N. Johnson Diseases National Institute of Allergy and Infectious R01AI192221 Jason W. Rosch Diseases National Inst...	U19AI109945
Defense Threat Reduction Agency	HDTRA1-12-1-0051, HDTRA1-14-1-0013

ODS de las Naciones Unidas

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Good health and well being

ASJC Scopus subject areas

Microbiology
General Immunology and Microbiology
Infectious Diseases

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abstract = "Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in West Africa. Filovirus disease is characterized by uncontrolled virus replication and the activation of host responses that contribute to pathogenesis. Underlying these phenomena is the potent suppression of host innate antiviral responses, particularly the type I interferon response, by viral proteins, which allows high levels of viral replication. In this Review, we describe the mechanisms used by filoviruses to block host innate immunity and discuss the links between immune evasion and filovirus pathogenesis.",

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Filovirus pathogenesis and immune evasion: Insights from Ebola virus and Marburg virus

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