From white spots to stem cells: the role of the Kit receptor in mammalian development

Roger A. Fleischman

doi:10.1016/0168-9525(93)90015-A

From white spots to stem cells: the role of the Kit receptor in mammalian development

Roger A. Fleischman

Internal Medicine

Producción científica: Review article › revisión exhaustiva

186 Citas (Scopus)

Resumen

The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.

Idioma original	English
Páginas (desde-hasta)	285-290
Número de páginas	6
Publicación	Trends in Genetics
Volumen	9
N.º	8
DOI	https://doi.org/10.1016/0168-9525(93)90015-A
Estado	Published - ago 1993

ASJC Scopus subject areas

Genetics

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10.1016/0168-9525(93)90015-A

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title = "From white spots to stem cells: the role of the Kit receptor in mammalian development",

abstract = "The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.",

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AU - Fleischman, Roger A.

PY - 1993/8

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N2 - The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.

AB - The Kit tyrosine kinase membrane receptor is essential for melanogenesis, gametogenesis and hematopoiesis during embryonic development and postnatal life. This review summarizes the genetic evidence implicating Kit and its ligand, Steel factor, in the control of stem cell proliferation, migration and survival, with emphasis on mutations in the human and mouse genes.

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UR - https://www.scopus.com/pages/publications/0027218845#tab=citedBy

U2 - 10.1016/0168-9525(93)90015-A

DO - 10.1016/0168-9525(93)90015-A

M3 - Review article

C2 - 7691001

AN - SCOPUS:0027218845

SN - 0168-9525

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JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

From white spots to stem cells: the role of the Kit receptor in mammalian development

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