Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

Robert C. Dickson; Chiranthani Sumanasekera; Robert L. Lester

doi:10.1016/j.plipres.2006.03.004

Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

Robert C. Dickson
, Chiranthani Sumanasekera
, Robert L. Lester

Molecular and Cellular Biochemistry

Producción científica: Review article › revisión exhaustiva

248 Citas (Scopus)

Resumen

We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly complete identification of genes involved in sphingolipid synthesis and breakdown. Other advances include roles for sphingolipid long-chain bases as signaling molecules that regulate growth, responses to heat stress, cell wall synthesis and repair, endocytosis and dynamics of the actin cytoskeleton. We touch briefly on other sphingolipid functions so that readers unfamiliar with the field will gain a broader view of sphingolipid research. These functions include roles in protein trafficking/exocytosis, lipid rafts or microdomains, calcium homeostasis, longevity and cellular aging, nutrient uptake, cross-talk with other lipids and the interaction of sphingolipids and antifungal drugs.

Idioma original	English
Páginas (desde-hasta)	447-465
Número de páginas	19
Publicación	Progress in Lipid Research
Volumen	45
N.º	6
DOI	https://doi.org/10.1016/j.plipres.2006.03.004
Estado	Published - nov 2006

Nota bibliográfica

Funding Information:
Work in the author’s laboratory was supported by research grants to RCD from the National Institutes of Health (GM41302 and AG024377). This publication was also made possible by Grant P20-RR020171 from the National Center for Research Resources, a component of the National Institutes of Health.

Financiación

Work in the author’s laboratory was supported by research grants to RCD from the National Institutes of Health (GM41302 and AG024377). This publication was also made possible by Grant P20-RR020171 from the National Center for Research Resources, a component of the National Institutes of Health.

Financiadores	Número del financiador
National Institutes of Health (NIH)	GM41302, P20-RR020171
National Institute on Aging	R01AG024377
National Center for Research Resources

ASJC Scopus subject areas

Biochemistry
Cell Biology

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10.1016/j.plipres.2006.03.004

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title = "Functions and metabolism of sphingolipids in Saccharomyces cerevisiae",

abstract = "We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly complete identification of genes involved in sphingolipid synthesis and breakdown. Other advances include roles for sphingolipid long-chain bases as signaling molecules that regulate growth, responses to heat stress, cell wall synthesis and repair, endocytosis and dynamics of the actin cytoskeleton. We touch briefly on other sphingolipid functions so that readers unfamiliar with the field will gain a broader view of sphingolipid research. These functions include roles in protein trafficking/exocytosis, lipid rafts or microdomains, calcium homeostasis, longevity and cellular aging, nutrient uptake, cross-talk with other lipids and the interaction of sphingolipids and antifungal drugs.",

author = "Dickson, \{Robert C.\} and Chiranthani Sumanasekera and Lester, \{Robert L.\}",

note = "Funding Information: Work in the author{\textquoteright}s laboratory was supported by research grants to RCD from the National Institutes of Health (GM41302 and AG024377). This publication was also made possible by Grant P20-RR020171 from the National Center for Research Resources, a component of the National Institutes of Health.",

year = "2006",

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T1 - Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

AU - Dickson, Robert C.

AU - Sumanasekera, Chiranthani

AU - Lester, Robert L.

N1 - Funding Information: Work in the author’s laboratory was supported by research grants to RCD from the National Institutes of Health (GM41302 and AG024377). This publication was also made possible by Grant P20-RR020171 from the National Center for Research Resources, a component of the National Institutes of Health.

PY - 2006/11

Y1 - 2006/11

N2 - We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly complete identification of genes involved in sphingolipid synthesis and breakdown. Other advances include roles for sphingolipid long-chain bases as signaling molecules that regulate growth, responses to heat stress, cell wall synthesis and repair, endocytosis and dynamics of the actin cytoskeleton. We touch briefly on other sphingolipid functions so that readers unfamiliar with the field will gain a broader view of sphingolipid research. These functions include roles in protein trafficking/exocytosis, lipid rafts or microdomains, calcium homeostasis, longevity and cellular aging, nutrient uptake, cross-talk with other lipids and the interaction of sphingolipids and antifungal drugs.

AB - We describe recent advances in understanding sphingolipid functions and metabolism in the baker's yeast Saccharomyces cerevisiae. One milestone has been reached in yeast sphingolipid research with the complete or nearly complete identification of genes involved in sphingolipid synthesis and breakdown. Other advances include roles for sphingolipid long-chain bases as signaling molecules that regulate growth, responses to heat stress, cell wall synthesis and repair, endocytosis and dynamics of the actin cytoskeleton. We touch briefly on other sphingolipid functions so that readers unfamiliar with the field will gain a broader view of sphingolipid research. These functions include roles in protein trafficking/exocytosis, lipid rafts or microdomains, calcium homeostasis, longevity and cellular aging, nutrient uptake, cross-talk with other lipids and the interaction of sphingolipids and antifungal drugs.

UR - https://www.scopus.com/pages/publications/33748309395

UR - https://www.scopus.com/pages/publications/33748309395#tab=citedBy

U2 - 10.1016/j.plipres.2006.03.004

DO - 10.1016/j.plipres.2006.03.004

M3 - Review article

C2 - 16730802

AN - SCOPUS:33748309395

SN - 0163-7827

VL - 45

SP - 447

EP - 465

JO - Progress in Lipid Research

JF - Progress in Lipid Research

IS - 6

ER -

Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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