Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group

Aimee N.C. Campbell; A. Kathleen Burlew; Constance Guille; Mia A. Haidamus; Denise A. Hien; Therese Killeen; Michelle R. Lofwall; Margaret M. Paschen-Wolff; Christi A. Patten; Dawn E. Sugarman; T. John Winhusen; Ludmila N. Bakhireva; Amy M. Loree; Shayna Mazel; Shelly F. Greenfield

doi:10.1016/j.josat.2025.209849

Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group

Aimee N.C. Campbell
, A. Kathleen Burlew
, Constance Guille
, Mia A. Haidamus
, Denise A. Hien
, Therese Killeen
, Michelle R. Lofwall
, Margaret M. Paschen-Wolff
, Christi A. Patten
, Dawn E. Sugarman
, T. John Winhusen
, Ludmila N. Bakhireva
, Amy M. Loree
, Shayna Mazel
, Shelly F. Greenfield

Producción científica: Comment/debate

Resumen

Despite rising rates of substance use disorders (SUD) in women and the narrowing of the SUD gender prevalence ratio in the U.S., large knowledge gaps in gender-specific treatment remain. The NIDA Clinical Trials Network (CTN) Gender Special Interest Group (GSIG) has provided opportunities to bring the gender lens to national multi-site clinical trials, ancillary studies, secondary data analyses, recommendations for data collection and demographic data, among other contributions to CTN and the SUD treatment field. This commentary provides background on gender differences and the knowledge gap, a history of the CTN GSIG, and its accomplishments via gender specific trials and key secondary analyses. The commentary will close with future directions and recommendations for research including improving the inclusion of intersectional identities in recruitment reach and analyses, reproductive health, pregnant and parenting people, and methodological considerations for clinical trials to enhance capacity to collect and understand data related to gender.

Idioma original	English
Número de artículo	209849
Publicación	Journal of substance use and addiction treatment
DOI	https://doi.org/10.1016/j.josat.2025.209849
Estado	Accepted/In press - 2025

Nota bibliográfica

Publisher Copyright:
© 2025

Financiación

The research trial data reported, as well as historical work of the Clinical Trials Network Gender Special Interest Group described in this manuscript, was supported in part by grants from the National Institutes of Health, National Institute on Drug Abuse ( NIDA ): UG1DA013035 (MPIs: McNeely, Nunes, Campbell); UG1DA015831 (MPIs: Weiss, D'Onofrio); UG1DA049468 (MPIs: Grando, Page); UG1DA013732 (PI: Winhusen); UG1DA013727 (MPIs: Barth, Brady); UG1DA040316 (PI: Bart); K23DA05078 (PI: Sugarman).

Financiadores

Número del financiador

National Institutes of Health (NIH)

Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse

UG1DA049468, UG1DA015831, UG1DA013035, UG1DA013727, K23DA05078, UG1DA040316, UG1DA013732

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatric Mental Health
Psychiatry and Mental health

Acceder al documento

10.1016/j.josat.2025.209849

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Campbell, A. N. C., Burlew, A. K., Guille, C., Haidamus, M. A., Hien, D. A., Killeen, T., Lofwall, M. R., Paschen-Wolff, M. M., Patten, C. A., Sugarman, D. E., Winhusen, T. J., Bakhireva, L. N., Loree, A. M., Mazel, S., & Greenfield, S. F. (Aceptado/En prensa). Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group. Journal of substance use and addiction treatment, Artículo 209849. https://doi.org/10.1016/j.josat.2025.209849

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title = "Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group",

abstract = "Despite rising rates of substance use disorders (SUD) in women and the narrowing of the SUD gender prevalence ratio in the U.S., large knowledge gaps in gender-specific treatment remain. The NIDA Clinical Trials Network (CTN) Gender Special Interest Group (GSIG) has provided opportunities to bring the gender lens to national multi-site clinical trials, ancillary studies, secondary data analyses, recommendations for data collection and demographic data, among other contributions to CTN and the SUD treatment field. This commentary provides background on gender differences and the knowledge gap, a history of the CTN GSIG, and its accomplishments via gender specific trials and key secondary analyses. The commentary will close with future directions and recommendations for research including improving the inclusion of intersectional identities in recruitment reach and analyses, reproductive health, pregnant and parenting people, and methodological considerations for clinical trials to enhance capacity to collect and understand data related to gender.",

keywords = "Addiction treatment, Gender, Perinatal, Sex, Substance use disorders",

author = "Campbell, \{Aimee N.C.\} and Burlew, \{A. Kathleen\} and Constance Guille and Haidamus, \{Mia A.\} and Hien, \{Denise A.\} and Therese Killeen and Lofwall, \{Michelle R.\} and Paschen-Wolff, \{Margaret M.\} and Patten, \{Christi A.\} and Sugarman, \{Dawn E.\} and Winhusen, \{T. John\} and Bakhireva, \{Ludmila N.\} and Loree, \{Amy M.\} and Shayna Mazel and Greenfield, \{Shelly F.\}",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

doi = "10.1016/j.josat.2025.209849",

language = "English",

}

Campbell, ANC, Burlew, AK, Guille, C, Haidamus, MA, Hien, DA, Killeen, T, Lofwall, MR, Paschen-Wolff, MM, Patten, CA, Sugarman, DE, Winhusen, TJ, Bakhireva, LN, Loree, AM, Mazel, S & Greenfield, SF 2025, 'Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group', Journal of substance use and addiction treatment. https://doi.org/10.1016/j.josat.2025.209849

TY - JOUR

T1 - Gender-specific addiction research needed now more than ever

T2 - Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group

AU - Campbell, Aimee N.C.

AU - Burlew, A. Kathleen

AU - Guille, Constance

AU - Haidamus, Mia A.

AU - Hien, Denise A.

AU - Killeen, Therese

AU - Lofwall, Michelle R.

AU - Paschen-Wolff, Margaret M.

AU - Patten, Christi A.

AU - Sugarman, Dawn E.

AU - Winhusen, T. John

AU - Bakhireva, Ludmila N.

AU - Loree, Amy M.

AU - Mazel, Shayna

AU - Greenfield, Shelly F.

PY - 2025

Y1 - 2025

N2 - Despite rising rates of substance use disorders (SUD) in women and the narrowing of the SUD gender prevalence ratio in the U.S., large knowledge gaps in gender-specific treatment remain. The NIDA Clinical Trials Network (CTN) Gender Special Interest Group (GSIG) has provided opportunities to bring the gender lens to national multi-site clinical trials, ancillary studies, secondary data analyses, recommendations for data collection and demographic data, among other contributions to CTN and the SUD treatment field. This commentary provides background on gender differences and the knowledge gap, a history of the CTN GSIG, and its accomplishments via gender specific trials and key secondary analyses. The commentary will close with future directions and recommendations for research including improving the inclusion of intersectional identities in recruitment reach and analyses, reproductive health, pregnant and parenting people, and methodological considerations for clinical trials to enhance capacity to collect and understand data related to gender.

AB - Despite rising rates of substance use disorders (SUD) in women and the narrowing of the SUD gender prevalence ratio in the U.S., large knowledge gaps in gender-specific treatment remain. The NIDA Clinical Trials Network (CTN) Gender Special Interest Group (GSIG) has provided opportunities to bring the gender lens to national multi-site clinical trials, ancillary studies, secondary data analyses, recommendations for data collection and demographic data, among other contributions to CTN and the SUD treatment field. This commentary provides background on gender differences and the knowledge gap, a history of the CTN GSIG, and its accomplishments via gender specific trials and key secondary analyses. The commentary will close with future directions and recommendations for research including improving the inclusion of intersectional identities in recruitment reach and analyses, reproductive health, pregnant and parenting people, and methodological considerations for clinical trials to enhance capacity to collect and understand data related to gender.

KW - Addiction treatment

KW - Gender

KW - Perinatal

KW - Sex

KW - Substance use disorders

UR - https://www.scopus.com/pages/publications/105023700502

UR - https://www.scopus.com/pages/publications/105023700502#tab=citedBy

U2 - 10.1016/j.josat.2025.209849

DO - 10.1016/j.josat.2025.209849

M3 - Comment/debate

AN - SCOPUS:105023700502

SN - 2949-8767

JO - Journal of substance use and addiction treatment

JF - Journal of substance use and addiction treatment

M1 - 209849

ER -

Gender-specific addiction research needed now more than ever: Reflections from 25 years of the NIDA Clinical Trials Network Gender Special Interest Group

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

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