Genetic loci associated with circulating levels of very long-chain saturated fatty acids

Rozenn N. Lemaitre; Irena B. King; Edmond K. Kabagambe; Jason H.Y. Wu; Barbara McKnight; Ani Manichaikul; Weihua Guan; Qi Sun; Daniel I. Chasman; Millennia Foy; Lu Wang; Jingwen Zhu; David S. Siscovick; Michael Y. Tsai; Donna K. Arnett; Bruce M. Psaty; Luc Djousse; Yii Der I. Chen; Weihong Tang; Lu Chen Weng; Hongyu Wu; Majken K. Jensen; Audrey Y. Chu; David R. Jacobs; Stephen S. Rich; Dariush Mozaffarian; Lyn Steffen; Eric B. Rimm; Frank B. Hu; Paul M. Ridker; Myriam Fornage; Yechiel Friedlander

doi:10.1194/jlr.M052456

Genetic loci associated with circulating levels of very long-chain saturated fatty acids

Rozenn N. Lemaitre
, Irena B. King
, Edmond K. Kabagambe
, Jason H.Y. Wu
, Barbara McKnight
, Ani Manichaikul
, Weihua Guan
, Qi Sun
, Daniel I. Chasman
, Millennia Foy
, Lu Wang
, Jingwen Zhu
, David S. Siscovick
, Michael Y. Tsai
, Donna K. Arnett
, Bruce M. Psaty
, Luc Djousse
, Yii Der I. Chen
, Weihong Tang
, Lu Chen Weng

Hongyu Wu, Majken K. Jensen, Audrey Y. Chu, David R. Jacobs, Stephen S. Rich, Dariush Mozaffarian, Lyn Steffen, Eric B. Rimm, Frank B. Hu, Paul M. Ridker, Myriam Fornage, Yechiel Friedlander

Producción científica: Article › revisión exhaustiva

39 Citas (Scopus)

Resumen

Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have benefi cial biological properties. Whether genetic factors infl uence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 ( SPTLC3 ), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 ( CERS4 ).

Idioma original	English
Páginas (desde-hasta)	176-184
Número de páginas	9
Publicación	Journal of Lipid Research
Volumen	56
N.º	1
DOI	https://doi.org/10.1194/jlr.M052456
Estado	Published - ene 1 2015

Nota bibliográfica

Publisher Copyright:
Copyright © 2015 by the American Society for Biochemistry and Molecular Biology, Inc.

Financiación

Financiadores	Número del financiador
American the American Heart Association
National Heart, Lung, and Blood Institute (NHLBI)	R01-HL-084099, HL105756, U01HL080295, R01HL105756, HHSN268201100006C, HHSN268201100005C, HHSN268201100008C, HHSN268201100007C, HHSN268201100009C, R01HL120393, HHSN268201100011C, HHSN268201100010C, R01HL103612, R01HL087652, HHSN268201100012C
National Human Genome Research Institute
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council
National Institute on Aging	R01AG023629
National Institutes of Health (NIH)
National Childhood Cancer Registry – National Cancer Institute	P01CA087969
National Childhood Cancer Registry – National Cancer Institute

ASJC Scopus subject areas

Biochemistry
Endocrinology
Cell Biology

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10.1194/jlr.M052456

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Lemaitre, R. N., King, I. B., Kabagambe, E. K., Wu, J. H. Y., McKnight, B., Manichaikul, A., Guan, W., Sun, Q., Chasman, D. I., Foy, M., Wang, L., Zhu, J., Siscovick, D. S., Tsai, M. Y., Arnett, D. K., Psaty, B. M., Djousse, L., Chen, Y. D. I., Tang, W., ... Friedlander, Y. (2015). Genetic loci associated with circulating levels of very long-chain saturated fatty acids. Journal of Lipid Research, 56(1), 176-184. https://doi.org/10.1194/jlr.M052456

@article{83ad19c4267448e2b61309ff8598b144,

title = "Genetic loci associated with circulating levels of very long-chain saturated fatty acids",

abstract = "Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have benefi cial biological properties. Whether genetic factors infl uence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 ( SPTLC3 ), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 ( CERS4 ).",

author = "Lemaitre, \{Rozenn N.\} and King, \{Irena B.\} and Kabagambe, \{Edmond K.\} and Wu, \{Jason H.Y.\} and Barbara McKnight and Ani Manichaikul and Weihua Guan and Qi Sun and Chasman, \{Daniel I.\} and Millennia Foy and Lu Wang and Jingwen Zhu and Siscovick, \{David S.\} and Tsai, \{Michael Y.\} and Arnett, \{Donna K.\} and Psaty, \{Bruce M.\} and Luc Djousse and Chen, \{Yii Der I.\} and Weihong Tang and Weng, \{Lu Chen\} and Hongyu Wu and Jensen, \{Majken K.\} and Chu, \{Audrey Y.\} and Jacobs, \{David R.\} and Rich, \{Stephen S.\} and Dariush Mozaffarian and Lyn Steffen and Rimm, \{Eric B.\} and Hu, \{Frank B.\} and Ridker, \{Paul M.\} and Myriam Fornage and Yechiel Friedlander",

note = "Publisher Copyright: Copyright {\textcopyright} 2015 by the American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jan,

day = "1",

doi = "10.1194/jlr.M052456",

language = "English",

volume = "56",

pages = "176--184",

number = "1",

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Lemaitre, RN, King, IB, Kabagambe, EK, Wu, JHY, McKnight, B, Manichaikul, A, Guan, W, Sun, Q, Chasman, DI, Foy, M, Wang, L, Zhu, J, Siscovick, DS, Tsai, MY, Arnett, DK, Psaty, BM, Djousse, L, Chen, YDI, Tang, W, Weng, LC, Wu, H, Jensen, MK, Chu, AY, Jacobs, DR, Rich, SS, Mozaffarian, D, Steffen, L, Rimm, EB, Hu, FB, Ridker, PM, Fornage, M & Friedlander, Y 2015, 'Genetic loci associated with circulating levels of very long-chain saturated fatty acids', Journal of Lipid Research, vol. 56, n.º 1, pp. 176-184. https://doi.org/10.1194/jlr.M052456

TY - JOUR

T1 - Genetic loci associated with circulating levels of very long-chain saturated fatty acids

AU - Lemaitre, Rozenn N.

AU - King, Irena B.

AU - Kabagambe, Edmond K.

AU - Wu, Jason H.Y.

AU - McKnight, Barbara

AU - Manichaikul, Ani

AU - Guan, Weihua

AU - Sun, Qi

AU - Chasman, Daniel I.

AU - Foy, Millennia

AU - Wang, Lu

AU - Zhu, Jingwen

AU - Siscovick, David S.

AU - Tsai, Michael Y.

AU - Arnett, Donna K.

AU - Psaty, Bruce M.

AU - Djousse, Luc

AU - Chen, Yii Der I.

AU - Tang, Weihong

AU - Weng, Lu Chen

AU - Wu, Hongyu

AU - Jensen, Majken K.

AU - Chu, Audrey Y.

AU - Jacobs, David R.

AU - Rich, Stephen S.

AU - Mozaffarian, Dariush

AU - Steffen, Lyn

AU - Rimm, Eric B.

AU - Hu, Frank B.

AU - Ridker, Paul M.

AU - Fornage, Myriam

AU - Friedlander, Yechiel

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have benefi cial biological properties. Whether genetic factors infl uence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 ( SPTLC3 ), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 ( CERS4 ).

AB - Very long-chain saturated fatty acids (VLSFAs) are saturated fatty acids with 20 or more carbons. In contrast to the more abundant saturated fatty acids, such as palmitic acid, there is growing evidence that circulating VLSFAs may have benefi cial biological properties. Whether genetic factors infl uence circulating levels of VLSFAs is not known. We investigated the association of common genetic variation with plasma phospholipid/erythrocyte levels of three VLSFAs by performing genome-wide association studies in seven population-based cohorts comprising 10,129 subjects of European ancestry. We observed associations of circulating VLSFA concentrations with common variants in two genes, serine palmitoyl-transferase long-chain base subunit 3 ( SPTLC3 ), a gene involved in the rate-limiting step of de novo sphingolipid synthesis, and ceramide synthase 4 ( CERS4 ).

UR - https://www.scopus.com/pages/publications/84920668691

UR - https://www.scopus.com/pages/publications/84920668691#tab=citedBy

U2 - 10.1194/jlr.M052456

DO - 10.1194/jlr.M052456

M3 - Article

C2 - 25378659

AN - SCOPUS:84920668691

SN - 0022-2275

VL - 56

SP - 176

EP - 184

JO - Journal of Lipid Research

JF - Journal of Lipid Research

IS - 1

ER -

Genetic loci associated with circulating levels of very long-chain saturated fatty acids

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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