Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik; Ishita Parikh; Jared B. Vasquez; Conor Smith; Leon Tai; Guojun Bu; Mary Jo Ladu; David W. Fardo; G. William Rebeck; Steven Estus

doi:10.1186/s13024-015-0048-1

Genetics ignite focus on microglial inflammation in Alzheimer's disease

Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo Ladu, David W. Fardo, G. William Rebeck, Steven Estus

Producción científica: Article › revisión exhaustiva

141 Citas (Scopus)

Resumen

In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.

Idioma original	English
Número de artículo	48
Publicación	Molecular Neurodegeneration
Volumen	10
N.º	1
DOI	https://doi.org/10.1186/s13024-015-0048-1
Estado	Published - dic 1 2015

Nota bibliográfica

Publisher Copyright:
© 2015 Malik et al.

Financiación

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute on Aging	K25AG043546
National Institute on Aging

ASJC Scopus subject areas

Molecular Biology
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1186/s13024-015-0048-1

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abstract = "In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.",

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AU - Malik, Manasi

AU - Parikh, Ishita

AU - Vasquez, Jared B.

AU - Smith, Conor

AU - Tai, Leon

AU - Bu, Guojun

AU - Ladu, Mary Jo

AU - Fardo, David W.

AU - Rebeck, G. William

AU - Estus, Steven

PY - 2015/12/1

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AB - In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD.

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KW - APOE

KW - Alzheimer's disease

KW - CD33

KW - CR1

KW - GWAS

KW - Microglia

KW - Neuroinflammation

KW - SHIP1

KW - TREM2

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Genetics ignite focus on microglial inflammation in Alzheimer's disease

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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