Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

doi:10.1038/s41467-020-18489-3

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

Producción científica: Article › revisión exhaustiva

89 Citas (Scopus)

Resumen

Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP and GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN) (N_total = 842,717) and identified 99 loci for smoking initiation and 13 loci for smoking cessation. Overall, this large GWAS of longitudinal smoking phenotype in multiple populations, combined with a meta-GWAS for smoking status, adds new insights into the genetic vulnerability for smoking behavior.

Idioma original	English
Número de artículo	5302
Publicación	Nature Communications
Volumen	11
N.º	1
DOI	https://doi.org/10.1038/s41467-020-18489-3
Estado	Published - dic 1 2020

Nota bibliográfica

Publisher Copyright:
© 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Financiación

This research is based on data from the Million Veteran Program, Office of Research and Development, Veterans Health Administration, and was supported by award #MVP004. This publication does not represent the views of the Department of Veterans Affairs or the United States Government. Our study was supported by National Institute on Drug Abuse grants R01DA038632, R01DA047063, and R01DA047820. We thank all participants in the MVP who allowed access to their electronic health records and provided blood samples for genomic analyses. We thank all authors and consortia for making their summary statistics publicly available to the research community.

Financiadores	Número del financiador
Million Veteran Program Science Meeting
Veterans Health Administration
National Institutes of Health (NIH)	1I01BX003341
National Institute on Drug Abuse	R01DA047820, R01DA042691, R01DA038632, R01DA047063
Biomedical Laboratory Research and Development, VA Office of Research and Development

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

Acceder al documento

10.1038/s41467-020-18489-3

Otros archivos y enlaces

Citar esto

@article{e088f8b6b71e4f929c7db5995aa824ef,

title = "Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals",

abstract = "Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP and GWAS \& Sequencing Consortium of Alcohol and Nicotine use (GSCAN) (Ntotal = 842,717) and identified 99 loci for smoking initiation and 13 loci for smoking cessation. Overall, this large GWAS of longitudinal smoking phenotype in multiple populations, combined with a meta-GWAS for smoking status, adds new insights into the genetic vulnerability for smoking behavior.",

author = "Ke Xu and Boyang Li and McGinnis, \{Kathleen A.\} and Rachel Vickers-Smith and Cecilia Dao and Ning Sun and Kember, \{Rachel L.\} and Hang Zhou and Becker, \{William C.\} and Joel Gelernter and Kranzler, \{Henry R.\} and Hongyu Zhao and Justice, \{Amy C.\}",

note = "Publisher Copyright: {\textcopyright} 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

year = "2020",

month = dec,

day = "1",

doi = "10.1038/s41467-020-18489-3",

language = "English",

volume = "11",

number = "1",

}

TY - JOUR

T1 - Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

AU - Xu, Ke

AU - Li, Boyang

AU - McGinnis, Kathleen A.

AU - Vickers-Smith, Rachel

AU - Dao, Cecilia

AU - Sun, Ning

AU - Kember, Rachel L.

AU - Zhou, Hang

AU - Becker, William C.

AU - Gelernter, Joel

AU - Kranzler, Henry R.

AU - Zhao, Hongyu

AU - Justice, Amy C.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP and GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN) (Ntotal = 842,717) and identified 99 loci for smoking initiation and 13 loci for smoking cessation. Overall, this large GWAS of longitudinal smoking phenotype in multiple populations, combined with a meta-GWAS for smoking status, adds new insights into the genetic vulnerability for smoking behavior.

AB - Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we identified 18 loci for smoking trajectory of current versus never in European Americans, one locus in African Americans, and one in Hispanic Americans. Functional annotations prioritized several dozen genes where significant loci co-localized with either expression quantitative trait loci or chromatin interactions. The smoking trajectories were genetically correlated with 209 complex traits, for 33 of which smoking was either a causal or a consequential factor. We also performed European-ancestry meta-analyses for smoking status in the MVP and GWAS & Sequencing Consortium of Alcohol and Nicotine use (GSCAN) (Ntotal = 842,717) and identified 99 loci for smoking initiation and 13 loci for smoking cessation. Overall, this large GWAS of longitudinal smoking phenotype in multiple populations, combined with a meta-GWAS for smoking status, adds new insights into the genetic vulnerability for smoking behavior.

UR - https://www.scopus.com/pages/publications/85092943292

UR - https://www.scopus.com/pages/publications/85092943292#tab=citedBy

U2 - 10.1038/s41467-020-18489-3

DO - 10.1038/s41467-020-18489-3

M3 - Article

C2 - 33082346

AN - SCOPUS:85092943292

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 5302

ER -

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto