Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

Zizhang Sheng; Zhiguang Ran; Dan Wang; Adam D. Hoppe; Randy Simonson; Suvobrata Chakravarty; Ben M. Hause; Feng Li

doi:10.1007/s00705-013-1815-3

Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

Zizhang Sheng
, Zhiguang Ran
, Dan Wang
, Adam D. Hoppe
, Randy Simonson
, Suvobrata Chakravarty
, Ben M. Hause
, Feng Li

Producción científica: Article › revisión exhaustiva

23 Citas (Scopus)

Resumen

We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae.

Idioma original	English
Páginas (desde-hasta)	249-255
Número de páginas	7
Publicación	Archives of Virology
Volumen	159
N.º	2
DOI	https://doi.org/10.1007/s00705-013-1815-3
Estado	Published - feb 2014

Nota bibliográfica

Funding Information:
This research was supported in part by the SDSU AES Fund 3AH203, a Public Health Service grant (AI076125 to F.L.), and SD 2010 Research Center (Biological Control and Analysis of Applied Photonics, BCAAP) Fund (3SJ163 to F.L.). Research in the S.C. laboratory is supported by the SDSU AES to S.C. and the South Dakota 2010 Research Center, BCAAP (Biological Control and Analysis of Applied Photonics) Fund (3SG163 to S.C.).

Financiación

This research was supported in part by the SDSU AES Fund 3AH203, a Public Health Service grant (AI076125 to F.L.), and SD 2010 Research Center (Biological Control and Analysis of Applied Photonics, BCAAP) Fund (3SJ163 to F.L.). Research in the S.C. laboratory is supported by the SDSU AES to S.C. and the South Dakota 2010 Research Center, BCAAP (Biological Control and Analysis of Applied Photonics) Fund (3SG163 to S.C.).

Financiadores	Número del financiador
SDSU AES	3AH203
South Dakota 2010 Research Center	3SG163
National Institute of Allergy and Infectious Diseases	K02AI076125
U.S. Public Health Service	AI076125, 3SJ163

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Virology

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10.1007/s00705-013-1815-3

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title = "Genomic and evolutionary characterization of a novel influenza-C-like virus from swine",

abstract = "We recently described the isolation of a novel influenza virus from swine exhibiting respiratory disease in the United States that is distantly related to human influenza C virus. Based on genetic, biochemical and morphological analysis, the virus was provisionally classified as C/swine/Oklahoma/1334/2011 (C/OK). To further understand the genetics and evolution of this novel pathogen, we performed a comprehensive analysis of its sequence and phylogeny. The results demonstrated that C/OK and human influenza C viruses share a conserved array of predicted functional domains in the viral RNA genome replication and viral entry machinery but vary at key functional sites. Furthermore, our evolutionary analysis showed that homologous genes of C/OK and human influenza C viruses diverged from each other an estimated several hundred to several thousand years ago. Taken together, the findings described in this study support and extend our previous observations that C/OK is a genetically and evolutionarily distinct influenza virus in the family Orthomyxoviridae.",

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AU - Chakravarty, Suvobrata

AU - Hause, Ben M.

AU - Li, Feng

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PY - 2014/2

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Genomic and evolutionary characterization of a novel influenza-C-like virus from swine

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Financiación

ODS de las Naciones Unidas

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