Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase

Michel Desjardins; Sylvie Garneau; Julie Desgagnés; Lucille Lacoste; Fu Yang; Jacques Lapointe; Robert Chênevert

doi:10.1006/bioo.1998.1082

Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase

Michel Desjardins
, Sylvie Garneau
, Julie Desgagnés
, Lucille Lacoste
, Fu Yang
, Jacques Lapointe
, Robert Chênevert

Producción científica: Article › revisión exhaustiva

19 Citas (Scopus)

Resumen

Glutamol adenylate 10 was a competitive inhibitor (K(i) = 3 μM) of glutamyl-tRNA synthetase from Escherichia coli. The N⁶-benzoyl adenine derivative 9 was also an inhibitor (K(i) ~ 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.

Idioma original	English
Páginas (desde-hasta)	1-13
Número de páginas	13
Publicación	Bioorganic Chemistry
Volumen	26
N.º	1
DOI	https://doi.org/10.1006/bioo.1998.1082
Estado	Published - jun 1998

Nota bibliográfica

Funding Information:
This work was supported by Grants OGP0009597 (to J.L.) and CPG0164048 (to R.C. and J.L.) from the Natural Sciences and Engineering Research Council of Canada and by Grant 98-ER-2481 from the ‘‘Fonds FCAR du Ministère de l’Éducation du Québec’’ (to R.C. and J.L.).

Financiación

This work was supported by Grants OGP0009597 (to J.L.) and CPG0164048 (to R.C. and J.L.) from the Natural Sciences and Engineering Research Council of Canada and by Grant 98-ER-2481 from the ‘‘Fonds FCAR du Ministère de l’Éducation du Québec’’ (to R.C. and J.L.).

Financiadores	Número del financiador
Ministère de l'Éducation, du Loisir et du Sport Québec
Natural Sciences and Engineering Research Council of Canada	98-ER-2481
Fonds pour la Formation de Chercheurs et l'Aide à la Recherche

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

Acceder al documento

10.1006/bioo.1998.1082

Otros archivos y enlaces

Citar esto

@article{a43bb63d15d14156b48ecedac5ab9619,

title = "Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase",

abstract = "Glutamol adenylate 10 was a competitive inhibitor (K(i) = 3 μM) of glutamyl-tRNA synthetase from Escherichia coli. The N6-benzoyl adenine derivative 9 was also an inhibitor (K(i) \textasciitilde{} 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.",

author = "Michel Desjardins and Sylvie Garneau and Julie Desgagn{\'e}s and Lucille Lacoste and Fu Yang and Jacques Lapointe and Robert Ch{\^e}nevert",

note = "Funding Information: This work was supported by Grants OGP0009597 (to J.L.) and CPG0164048 (to R.C. and J.L.) from the Natural Sciences and Engineering Research Council of Canada and by Grant 98-ER-2481 from the {\textquoteleft}{\textquoteleft}Fonds FCAR du Minist{\`e}re de l{\textquoteright}{\'E}ducation du Qu{\'e}bec{\textquoteright}{\textquoteright} (to R.C. and J.L.).",

year = "1998",

month = jun,

doi = "10.1006/bioo.1998.1082",

language = "English",

volume = "26",

pages = "1--13",

number = "1",

}

TY - JOUR

T1 - Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase

AU - Desjardins, Michel

AU - Garneau, Sylvie

AU - Desgagnés, Julie

AU - Lacoste, Lucille

AU - Yang, Fu

AU - Lapointe, Jacques

AU - Chênevert, Robert

N1 - Funding Information: This work was supported by Grants OGP0009597 (to J.L.) and CPG0164048 (to R.C. and J.L.) from the Natural Sciences and Engineering Research Council of Canada and by Grant 98-ER-2481 from the ‘‘Fonds FCAR du Ministère de l’Éducation du Québec’’ (to R.C. and J.L.).

PY - 1998/6

Y1 - 1998/6

N2 - Glutamol adenylate 10 was a competitive inhibitor (K(i) = 3 μM) of glutamyl-tRNA synthetase from Escherichia coli. The N6-benzoyl adenine derivative 9 was also an inhibitor (K(i) ~ 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.

AB - Glutamol adenylate 10 was a competitive inhibitor (K(i) = 3 μM) of glutamyl-tRNA synthetase from Escherichia coli. The N6-benzoyl adenine derivative 9 was also an inhibitor (K(i) ~ 60 μM). Replacement of adenine by other bases (purine, cytosine, dihydrocytosine, uridine) resulted in a more than 1000-fold loss in activity, indicating the important contribution of the adenine ring to the enzyme binding.

UR - https://www.scopus.com/pages/publications/0031831834

UR - https://www.scopus.com/pages/publications/0031831834#tab=citedBy

U2 - 10.1006/bioo.1998.1082

DO - 10.1006/bioo.1998.1082

M3 - Article

AN - SCOPUS:0031831834

SN - 0045-2068

VL - 26

SP - 1

EP - 13

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

IS - 1

ER -

Glutamyl adenylate analogues are inhibitors of glutamyl-tRNA synthetase

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto