Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair; Elizabeth A. Brundage; Katherine L. Thompson; Arnold Stromberg; Maya Guglin; Brandon J. Biesiadecki; Kenneth S. Campbell

doi:10.1016/j.jacbts.2020.05.014

Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Cheavar A. Blair
, Elizabeth A. Brundage
, Katherine L. Thompson
, Arnold Stromberg
, Maya Guglin
, Brandon J. Biesiadecki
, Kenneth S. Campbell

Producción científica: Article › revisión exhaustiva

28 Citas (Scopus)

Resumen

This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca²⁺) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca²⁺ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

Idioma original	English
Páginas (desde-hasta)	786-798
Número de páginas	13
Publicación	JACC: Basic to Translational Science
Volumen	5
N.º	8
DOI	https://doi.org/10.1016/j.jacbts.2020.05.014
Estado	Published - ago 2020

Nota bibliográfica

Publisher Copyright:
© 2020 The Authors

Financiación

The authors acknowledge support from the Gill Cardiovascular Biorepository at the University of Kentucky and from the patients, organ donors, and families who donated samples. Dr. Biesiadecki was supported by the National Institutes of Health (HL114940). Dr. Campbell was supported by the American Heart Association (GRNT25460003, TPA34860008), the National Institutes of Health (TR033173, HL133359, and HL146676. The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Financiadores	Número del financiador
National Institutes of Health (NIH)	HL114940
American the American Heart Association	TPA34860008, GRNT25460003, HL146676, HL133359, TR033173
University of Kentucky

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Acceder al documento

10.1016/j.jacbts.2020.05.014

Otros archivos y enlaces

Citar esto

@article{6c4882bd478e4c1081a07df8bfa50a1c,

title = "Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles",

abstract = "This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30\% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.",

keywords = "Ca sensitivity, heart failure, human myocardium, myofilament proteins, ventricular function",

author = "Blair, \{Cheavar A.\} and Brundage, \{Elizabeth A.\} and Thompson, \{Katherine L.\} and Arnold Stromberg and Maya Guglin and Biesiadecki, \{Brandon J.\} and Campbell, \{Kenneth S.\}",

note = "Publisher Copyright: {\textcopyright} 2020 The Authors",

year = "2020",

month = aug,

doi = "10.1016/j.jacbts.2020.05.014",

language = "English",

volume = "5",

pages = "786--798",

number = "8",

}

TY - JOUR

T1 - Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

AU - Blair, Cheavar A.

AU - Brundage, Elizabeth A.

AU - Thompson, Katherine L.

AU - Stromberg, Arnold

AU - Guglin, Maya

AU - Biesiadecki, Brandon J.

AU - Campbell, Kenneth S.

PY - 2020/8

Y1 - 2020/8

N2 - This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

AB - This study measured how heart failure affects the contractile properties of the human myocardium from the left and right ventricles. The data showed that maximum force and maximum power were reduced by approximately 30% in multicellular preparations from both ventricles, possibly because of ventricular remodeling (e.g., cellular disarray and/or excess fibrosis). Heart failure increased the calcium (Ca2+) sensitivity of contraction in both ventricles, but the effect was bigger in right ventricular samples. The changes in Ca2+ sensitivity were associated with ventricle-specific changes in the phosphorylation of troponin I, which indicated that adrenergic stimulation might induce different effects in the left and right ventricles.

KW - Ca sensitivity

KW - heart failure

KW - human myocardium

KW - myofilament proteins

KW - ventricular function

UR - https://www.scopus.com/pages/publications/85089295695

UR - https://www.scopus.com/pages/publications/85089295695#tab=citedBy

U2 - 10.1016/j.jacbts.2020.05.014

DO - 10.1016/j.jacbts.2020.05.014

M3 - Article

AN - SCOPUS:85089295695

SN - 2452-302X

VL - 5

SP - 786

EP - 798

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 8

ER -

Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto