High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Baoying Yuan; Changshun Wu; Xingwen Wang; Dan Wang; Huiling Liu; Ling Guo; Xiang An Li; Junqing Han; Hong Feng

doi:10.1007/s13277-015-4141-4

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

Baoying Yuan
, Changshun Wu
, Xingwen Wang
, Dan Wang
, Huiling Liu
, Ling Guo
, Xiang An Li
, Junqing Han
, Hong Feng

Physiology

Producción científica: Article › revisión exhaustiva

64 Citas (Scopus)

Resumen

Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

Idioma original	English
Páginas (desde-hasta)	3581-3588
Número de páginas	8
Publicación	Tumor Biology
Volumen	37
N.º	3
DOI	https://doi.org/10.1007/s13277-015-4141-4
Estado	Published - mar 1 2016

Nota bibliográfica

Publisher Copyright:
© 2015, International Society of Oncology and BioMarkers (ISOBM).

Financiación

This work was supported by grants from the National Natural Science Foundation of China (No. 81201865 and 81202307), and Shandong Science and Technology Development Planning (No. 2011GSF11843 and 2012G0021822).

Financiadores	Número del financiador
Shandong Science and Technology Development Planning	2011GSF11843, 2012G0021822
National Natural Science Foundation of China (NSFC)	81201865, 81202307
National Natural Science Foundation of China (NSFC)

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ASJC Scopus subject areas

Cancer Research

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title = "High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer",

abstract = "Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 \% of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.",

keywords = "Breast cancer, Immunohistochemistry, Prognosis, Scavenger receptor class B type I",

author = "Baoying Yuan and Changshun Wu and Xingwen Wang and Dan Wang and Huiling Liu and Ling Guo and Li, \{Xiang An\} and Junqing Han and Hong Feng",

note = "Publisher Copyright: {\textcopyright} 2015, International Society of Oncology and BioMarkers (ISOBM).",

year = "2016",

month = mar,

day = "1",

doi = "10.1007/s13277-015-4141-4",

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T1 - High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

AU - Yuan, Baoying

AU - Wu, Changshun

AU - Wang, Xingwen

AU - Wang, Dan

AU - Liu, Huiling

AU - Guo, Ling

AU - Li, Xiang An

AU - Han, Junqing

AU - Feng, Hong

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

AB - Scavenger receptor class B type I (SR-BI) has been linked to the development and progression of breast cancer. However, its clinical significance in breast cancer remains unclear. Here, we evaluated SR-BI expression in a well-characterized breast cancer tissue microarray by immunohistochemistry. High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage (P = 0.002), larger tumor size (P = 0.023), lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan–Meier survival analysis revealed that patients with high SR-BI expression had significantly shorter overall survival (OS) (P = 0.004). Moreover, multivariate analysis with adjustment for other prognostic factors confirmed that SR-BI was an independent prognostic factor for patient outcome (P = 0.017). Overall, our study demonstrated that high SR-BI expression was related to conventional parameters indicative of more aggressive tumor type and may serve as a new prognostic marker for poor clinical outcome in human breast cancer.

KW - Breast cancer

KW - Immunohistochemistry

KW - Prognosis

KW - Scavenger receptor class B type I

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U2 - 10.1007/s13277-015-4141-4

DO - 10.1007/s13277-015-4141-4

M3 - Article

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AN - SCOPUS:84944704063

SN - 1010-4283

VL - 37

SP - 3581

EP - 3588

JO - Tumor Biology

JF - Tumor Biology

IS - 3

ER -

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer

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Nota bibliográfica

Financiación

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ASJC Scopus subject areas

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