Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

Zachary C. DeVries; Richard G. Santangelo; Alexis M. Barbarin; Coby Schal

doi:10.1371/journal.pone.0192462

Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

Zachary C. DeVries
, Richard G. Santangelo
, Alexis M. Barbarin
, Coby Schal

Producción científica: Article › revisión exhaustiva

35 Citas (Scopus)

Resumen

Histamine is used in bronchial and dermal provocation, but it is rarely considered an environmental risk factor in allergic disease. Because bed bugs defecate large amounts of histamine as a component of their aggregation pheromone, we sought to determine if histamine accumulates in household dust in bed bug infested homes, and the effects of bed bug eradication with spatial heat on histamine levels in dust. We collected dust in homes and analyzed for histamine before, and up to three months after bed bug eradication. Histamine levels in bed bug infested homes were remarkably high (mean = 54.6±18.9 μg/100 mg of sieved household dust) and significantly higher than in control homes not infested with bed bugs (mean < 2.5±1.9 μg/100 mg of sieved household dust). Heat treatments that eradicated the bed bug infestations failed to reduce histamine levels, even three months after treatment. We report a clear association between histamine levels in household dust and bed bug infestations. The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment.

Idioma original	English
Número de artículo	e0192462
Publicación	PLoS ONE
Volumen	13
N.º	2
DOI	https://doi.org/10.1371/journal.pone.0192462
Estado	Published - feb 2018

Nota bibliográfica

Publisher Copyright:
© 2018 DeVries et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Financiación

Funding for this study was provided by the Blanton J. Whitmire Endowment at North Carolina State University, the US Department of Housing and Urban Development Healthy Homes program (NCHHU0017-13) to CS, Alfred P. Sloan Foundation (2013-5-35 MBE) to CS and a National Institute of Environmental Health Sciences grant to the Center for Human Health and the Environment (CHHE, P30ES025128). ZCD received the David R. Nimocks Jr. Fellowship and scholarship awards from the Foundation for Agromedicine and Toxicology, Pi Chi Omega, and the Entomological Society of America.

Financiadores	Número del financiador
National Institute of Environmental Health Sciences (NIEHS)
U.S. Department of Housing and Urban Development Healthy Homes program	NCHHU0017-13
Alfred P Sloan Foundation	2013-5-35 MBE
Entomological Society of America
International Academy of Oral Medicine and Toxicology
University of North Carolina and North Carolina State University
Center for the Built Environment	P30ES025128

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title = "Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes",

abstract = "Histamine is used in bronchial and dermal provocation, but it is rarely considered an environmental risk factor in allergic disease. Because bed bugs defecate large amounts of histamine as a component of their aggregation pheromone, we sought to determine if histamine accumulates in household dust in bed bug infested homes, and the effects of bed bug eradication with spatial heat on histamine levels in dust. We collected dust in homes and analyzed for histamine before, and up to three months after bed bug eradication. Histamine levels in bed bug infested homes were remarkably high (mean = 54.6±18.9 μg/100 mg of sieved household dust) and significantly higher than in control homes not infested with bed bugs (mean < 2.5±1.9 μg/100 mg of sieved household dust). Heat treatments that eradicated the bed bug infestations failed to reduce histamine levels, even three months after treatment. We report a clear association between histamine levels in household dust and bed bug infestations. The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment.",

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Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

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