Resumen
Epigenetic deregulation is intimately associated with the development of human diseases. Intensive studies are currently underway to clarify the mechanism for the sake of achieving ideal diagnostic and therapeutic goals. It has been demonstrated that enzymes with histone-modifying activities can also target non-histone proteins, with the underlying mechanism remaining obscure. In this review, we focus on a novel histone mimicry strategy that may be wildly adapted during the non-histone substrate recognition process. Its potential clinical implications are also discussed.
| Idioma original | English |
|---|---|
| Páginas (desde-hasta) | 228-233 |
| Número de páginas | 6 |
| Publicación | Frontiers in Biology |
| Volumen | 8 |
| N.º | 2 |
| DOI | |
| Estado | Published - abr 2013 |
Nota bibliográfica
Funding Information:editing of this manuscript. This work was supported by grants from NIH (RO1CA125454), Susan G Komen Foundation (KG081310), Mary Kay Ash Foundation (to B.P. Zhou) and pre-doctoral fellowship (BC101068) from DoD Breast Cancer Research Program (to Y. Lin).
Financiación
editing of this manuscript. This work was supported by grants from NIH (RO1CA125454), Susan G Komen Foundation (KG081310), Mary Kay Ash Foundation (to B.P. Zhou) and pre-doctoral fellowship (BC101068) from DoD Breast Cancer Research Program (to Y. Lin).
| Financiadores | Número del financiador |
|---|---|
| National Institutes of Health (NIH) | RO1CA125454 |
| U.S. Department of Defense | |
| Mary Kay Ash Foundation | |
| Susan G Komen Foundation | KG081310 |
| B.P. Koirala Institute of Health Sciences | BC101068 |
ASJC Scopus subject areas
- Biotechnology
- Ecology, Evolution, Behavior and Systematics
- Ecology
- Genetics
ODS de las Naciones Unidas
Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible
