Homeostasis of Lipid Metabolism in Disorders of the Brain

Jennifer L. Johnson; Lance A. Johnson

doi:10.1016/B978-0-12-819641-0.00146-8

Homeostasis of Lipid Metabolism in Disorders of the Brain

Jennifer L. Johnson
, Lance A. Johnson

Producción científica: Chapter › revisión exhaustiva

2 Citas (Scopus)

Resumen

Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.

Idioma original	English
Título de la publicación alojada	Encyclopedia of Behavioral Neuroscience
Subtítulo de la publicación alojada	Volumes 1-3, Second edition
Páginas	V1-372-V1-382
Volumen	1-3
ISBN (versión digital)	9780128196410
DOI	https://doi.org/10.1016/B978-0-12-819641-0.00146-8
Estado	Published - ene 1 2021

Nota bibliográfica

Publisher Copyright:
© 2021 Elsevier Ltd. All rights reserved.

ASJC Scopus subject areas

General Medicine
General Neuroscience

Acceder al documento

10.1016/B978-0-12-819641-0.00146-8

Otros archivos y enlaces

Citar esto

@inbook{3334a6030f35433e9fea79033b9cf89c,

title = "Homeostasis of Lipid Metabolism in Disorders of the Brain",

abstract = "Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.",

keywords = "Cholesterol, Glycerophospholipids, Lipid metabolism, Lysosomal storage disorders, Membrane microdomains, Neurodegenerative diseases, Neurological disorders, Neuropsychiatric disorders, Polyunsaturated fatty acids, Sphingolipids",

author = "Johnson, \{Jennifer L.\} and Johnson, \{Lance A.\}",

year = "2021",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-819641-0.00146-8",

language = "English",

volume = "1-3",

pages = "V1--372--V1--382",

booktitle = "Encyclopedia of Behavioral Neuroscience",

}

TY - CHAP

T1 - Homeostasis of Lipid Metabolism in Disorders of the Brain

AU - Johnson, Jennifer L.

AU - Johnson, Lance A.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.

AB - Making up half of the brain's dry weight, lipids are essential for the brain's structure and function. Their importance in the brain is highlighted by the number of inherited and multifactorial neurological disorders that involve dysregulated lipid metabolism. However, it is unknown if lipids contribute to these disorders through direct or indirect mechanisms. In the present chapter, we highlight the function of lipids in the brain, the effects of their perturbations, and their critical role in several different neurological disorders.

KW - Cholesterol

KW - Glycerophospholipids

KW - Lipid metabolism

KW - Lysosomal storage disorders

KW - Membrane microdomains

KW - Neurodegenerative diseases

KW - Neurological disorders

KW - Neuropsychiatric disorders

KW - Polyunsaturated fatty acids

KW - Sphingolipids

UR - https://www.scopus.com/pages/publications/85172098203

UR - https://www.scopus.com/pages/publications/85172098203#tab=citedBy

U2 - 10.1016/B978-0-12-819641-0.00146-8

DO - 10.1016/B978-0-12-819641-0.00146-8

M3 - Chapter

AN - SCOPUS:85172098203

VL - 1-3

SP - V1-372-V1-382

BT - Encyclopedia of Behavioral Neuroscience

ER -

Homeostasis of Lipid Metabolism in Disorders of the Brain

Resumen

Nota bibliográfica

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto