Hurgadacin: A new steroid from Sinularia polydactyla

Mohamed Shaaban; Khaled A. Shaaban; Mohamed A. Ghani

doi:10.1016/j.steroids.2013.05.006

Hurgadacin: A new steroid from Sinularia polydactyla

Mohamed Shaaban
, Khaled A. Shaaban
, Mohamed A. Ghani

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

26 Citas (Scopus)

Resumen

Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3β,5α,6β- triol (2) and 24-methylenecholestane-1α,3β,5α,6β, 11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.

Idioma original	English
Páginas (desde-hasta)	866-873
Número de páginas	8
Publicación	Steroids
Volumen	78
N.º	9
DOI	https://doi.org/10.1016/j.steroids.2013.05.006
Estado	Published - 2013

Nota bibliográfica

Funding Information:
The authors are greatly thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, University of Göttingen, Germany, for his lab facilities and support. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. Mrs. F. Lissy and Mr. A. Kohl are deeply appreciated for biological activity testing and technical assistance, respectively. We thank Dr. Madan K. Kharel (College of Pharmacy, University of Kentucky, USA) for the insightful discussion regarding the biosynthesis of the Hurgadacin. M. S. thanks the German Academic Exchange Service (DAAD) for a short-term grant.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Financiación

The authors are greatly thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, University of Göttingen, Germany, for his lab facilities and support. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. Mrs. F. Lissy and Mr. A. Kohl are deeply appreciated for biological activity testing and technical assistance, respectively. We thank Dr. Madan K. Kharel (College of Pharmacy, University of Kentucky, USA) for the insightful discussion regarding the biosynthesis of the Hurgadacin. M. S. thanks the German Academic Exchange Service (DAAD) for a short-term grant.

Financiadores
Deutscher Akademischer Austauschdienst France

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology
Pharmacology
Clinical Biochemistry
Organic Chemistry

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10.1016/j.steroids.2013.05.006

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@article{adc83a007acd47d697334f5480dfac57,

title = "Hurgadacin: A new steroid from Sinularia polydactyla",

abstract = "Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3β,5α,6β- triol (2) and 24-methylenecholestane-1α,3β,5α,6β, 11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.",

keywords = "Biological activity, Hurgadacin, Sinularia polydactyla",

author = "Mohamed Shaaban and Shaaban, \{Khaled A.\} and Ghani, \{Mohamed A.\}",

note = "Funding Information: The authors are greatly thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, University of G{\"o}ttingen, Germany, for his lab facilities and support. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. Mrs. F. Lissy and Mr. A. Kohl are deeply appreciated for biological activity testing and technical assistance, respectively. We thank Dr. Madan K. Kharel (College of Pharmacy, University of Kentucky, USA) for the insightful discussion regarding the biosynthesis of the Hurgadacin. M. S. thanks the German Academic Exchange Service (DAAD) for a short-term grant. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2013",

doi = "10.1016/j.steroids.2013.05.006",

language = "English",

volume = "78",

pages = "866--873",

number = "9",

}

TY - JOUR

T1 - Hurgadacin

T2 - A new steroid from Sinularia polydactyla

AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Ghani, Mohamed A.

N1 - Funding Information: The authors are greatly thankful to Prof. H. Laatsch, Institute of Organic and Biomolecular Chemistry, University of Göttingen, Germany, for his lab facilities and support. We thank Dr. H. Frauendorf and Mr. R. Machinek for MS and NMR measurements. Mrs. F. Lissy and Mr. A. Kohl are deeply appreciated for biological activity testing and technical assistance, respectively. We thank Dr. Madan K. Kharel (College of Pharmacy, University of Kentucky, USA) for the insightful discussion regarding the biosynthesis of the Hurgadacin. M. S. thanks the German Academic Exchange Service (DAAD) for a short-term grant. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2013

Y1 - 2013

N2 - Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3β,5α,6β- triol (2) and 24-methylenecholestane-1α,3β,5α,6β, 11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.

AB - Hurgadacin (1), a 24,25-bishomo-26-methylenecholesterol was isolated from the soft coral Sinularia polydactyla, collected from the Red Sea, near Hurghada at the Egyptian coast. The new steroid 1 was isolated together with the closely related polyhydroxy steroids 24-methylenecholestane-3β,5α,6β- triol (2) and 24-methylenecholestane-1α,3β,5α,6β, 11α-pentol (3), in addition to the sesquiterpene lactiflorenol (4) and the trinorcarotenolide acetate peridinin (5), The structures of the isolated compounds were confirmed by intensive studies of their 1D and 2D NMR spectra and mass data. The antimicrobial and cytotoxic activities of the soft coral extract and the corresponding constituents were evaluated against diverse pathogenic microorganisms and brine shrimps, respectively.

KW - Biological activity

KW - Hurgadacin

KW - Sinularia polydactyla

UR - https://www.scopus.com/pages/publications/84884991608

UR - https://www.scopus.com/pages/publications/84884991608#tab=citedBy

U2 - 10.1016/j.steroids.2013.05.006

DO - 10.1016/j.steroids.2013.05.006

M3 - Article

C2 - 23685088

AN - SCOPUS:84884991608

SN - 0039-128X

VL - 78

SP - 866

EP - 873

JO - Steroids

JF - Steroids

IS - 9

ER -

Hurgadacin: A new steroid from Sinularia polydactyla

Resumen

Nota bibliográfica

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ASJC Scopus subject areas

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