Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Juan J. Araya; Huaping Zhang; Thomas E. Prisinzano; Lester A. Mitscher; Barbara N. Timmermann

doi:10.1016/j.phytochem.2011.03.007

Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Juan J. Araya
, Huaping Zhang
, Thomas E. Prisinzano
, Lester A. Mitscher
, Barbara N. Timmermann

Producción científica: Article › revisión exhaustiva

16 Citas (Scopus)

Resumen

Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

Idioma original	English
Páginas (desde-hasta)	935-941
Número de páginas	7
Publicación	Phytochemistry
Volumen	72
N.º	9
DOI	https://doi.org/10.1016/j.phytochem.2011.03.007
Estado	Published - jun 2011

Nota bibliográfica

Funding Information:
The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH.

Financiación

The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH.

Financiadores	Número del financiador
University of Kansas Center for Research	2506014-910/099
National Institutes of Health (NIH)
Office of Dietary Supplements	1R21AT004182-01A2
National Center for Complementary and Alternative Medicine
National Center for Complementary and Integrative Health	R21AT004182
Universidad de Costa Rica

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

Acceder al documento

10.1016/j.phytochem.2011.03.007

Otros archivos y enlaces

Citar esto

@article{bb890ba9e6754f79925e501db38f3d95,

title = "Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach",

abstract = "Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.",

keywords = "Alkaloids, Fractionation, Ginger, Natural products, Phase-trafficking, Zingerines",

author = "Araya, \{Juan J.\} and Huaping Zhang and Prisinzano, \{Thomas E.\} and Mitscher, \{Lester A.\} and Timmermann, \{Barbara N.\}",

note = "Funding Information: The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH. ",

year = "2011",

month = jun,

doi = "10.1016/j.phytochem.2011.03.007",

language = "English",

volume = "72",

pages = "935--941",

number = "9",

}

TY - JOUR

T1 - Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

AU - Araya, Juan J.

AU - Zhang, Huaping

AU - Prisinzano, Thomas E.

AU - Mitscher, Lester A.

AU - Timmermann, Barbara N.

N1 - Funding Information: The chemistry work was supported by NCCAM/ODS Grant 1R21AT004182-01A2 from the National Institutes of Health (NIH) and the University of Kansas Center for Research project 2506014-910/099 to B.N.T., J.A. thanks LASPAU-Fulbright program and the University of Costa Rica for financial support. J.A. also thanks Kimberly Lovell for assistance during chiral HPLC separations. The contents are solely the responsibilities of the authors and do not necessarily represent the official views of the NIH.

PY - 2011/6

Y1 - 2011/6

N2 - Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

AB - Three unprecedented purine-containing compounds, named [6]-, [8]-, and [10]-zingerines as they are 5-(6-amino-9H-purin-9-yl) analogs of [6]-, [8]-, and [10]-gingerols, respectively, were isolated from a methanolic extract of ginger rhizomes using a phase trafficking-based method that utilizes solid phase reagents allowing for fast and selective simultaneous separation of basic, acidic, and neutral components of natural products extracts.

KW - Alkaloids

KW - Fractionation

KW - Ginger

KW - Natural products

KW - Phase-trafficking

KW - Zingerines

UR - https://www.scopus.com/pages/publications/79955783342

UR - https://www.scopus.com/pages/publications/79955783342#tab=citedBy

U2 - 10.1016/j.phytochem.2011.03.007

DO - 10.1016/j.phytochem.2011.03.007

M3 - Article

C2 - 21497863

AN - SCOPUS:79955783342

SN - 0031-9422

VL - 72

SP - 935

EP - 941

JO - Phytochemistry

JF - Phytochemistry

IS - 9

ER -

Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto