Increased chloride transport in erythrocytes in Huntington's disease

W. A. Bialas; W. R. Markesbery; D. A. Butterfield

doi:10.1016/S0006-291X(80)80121-5

Increased chloride transport in erythrocytes in Huntington's disease

W. A. Bialas
, W. R. Markesbery
, D. A. Butterfield

Producción científica: Article › revisión exhaustiva

14 Citas (Scopus)

Resumen

Studies of ³⁶Cl⁻ efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for ³⁶Cl⁻ efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

Idioma original	English
Páginas (desde-hasta)	1895-1900
Número de páginas	6
Publicación	Topics in Catalysis
Volumen	95
N.º	4
DOI	https://doi.org/10.1016/S0006-291X(80)80121-5
Estado	Published - 1980

Nota bibliográfica

Funding Information:
This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.

Financiación

This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.

Financiadores	Número del financiador
National Institutes of Health (NIH)	N8-14221, NS-13791-03
Muscular Dystrophy Association

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Biophysics
Molecular Biology

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@article{6d7bc1b4840342cfae1e9a424aa8e4cf,

title = "Increased chloride transport in erythrocytes in Huntington's disease",

abstract = "Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].",

author = "Bialas, \{W. A.\} and Markesbery, \{W. R.\} and Butterfield, \{D. A.\}",

note = "Funding Information: This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.",

year = "1980",

doi = "10.1016/S0006-291X(80)80121-5",

language = "English",

volume = "95",

pages = "1895--1900",

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TY - JOUR

T1 - Increased chloride transport in erythrocytes in Huntington's disease

AU - Bialas, W. A.

AU - Markesbery, W. R.

AU - Butterfield, D. A.

N1 - Funding Information: This work was supported in part by the National Institutes of Health (NS-13791-03 and N8-14221) and the Muscular Dystrophy Association of America.

PY - 1980

Y1 - 1980

N2 - Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

AB - Studies of 36Cl− efflux across erythrocyte membranes in controls and Huntington's disease have been performed. An increased rate constant for 36Cl− efflux in fresh Huntington's disease erythrocytes compared to normal controls was observed (P<0.01) in blind studies. Chloride transport is regulated in human erythrocytes at the external aspect of Band 3, the major red cell transmembrane protein. The present results on tissue completely outside the central nervous system are consistent with our suggestion that Huntington's disease is associated with a generalized membrane defect located at the external cell surface [Butterfield et al (1980) Life Sciences 27, 609–615].

UR - https://www.scopus.com/pages/publications/0019208762

UR - https://www.scopus.com/pages/publications/0019208762#tab=citedBy

U2 - 10.1016/S0006-291X(80)80121-5

DO - 10.1016/S0006-291X(80)80121-5

M3 - Article

C2 - 6448058

AN - SCOPUS:0019208762

VL - 95

SP - 1895

EP - 1900

JO - Topics in Catalysis

JF - Topics in Catalysis

IS - 4

ER -

Increased chloride transport in erythrocytes in Huntington's disease

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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