Increasing Area Deprivation Index negatively impacts ovarian cancer survival

Demetra H. Hufnagel; Dineo Khabele; Fiona E. Yull; Pamela C. Hull; Joellen Schildkraut; Marta A. Crispens; Alicia Beeghly-Fadiel

doi:10.1016/j.canep.2021.102013

Increasing Area Deprivation Index negatively impacts ovarian cancer survival

Demetra H. Hufnagel
, Dineo Khabele
, Fiona E. Yull
, Pamela C. Hull
, Joellen Schildkraut
, Marta A. Crispens
, Alicia Beeghly-Fadiel

Producción científica: Article › revisión exhaustiva

47 Citas (Scopus)

Resumen

Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.

Idioma original	English
Número de artículo	102013
Publicación	Cancer Epidemiology
Volumen	74
DOI	https://doi.org/10.1016/j.canep.2021.102013
Estado	Published - oct 2021

Nota bibliográfica

Publisher Copyright:
© 2021

Financiación

ABF, FEY, and MAC were supported in part by the National Institutes of Health (NIH) National Cancer Institute (NCI) Precision Medicine and Health Disparities Collaborative (PMHDC) Pilot Study U54 MD010722. ABF, MAC, DK, and FEY were supported in part by the NIH NCI grant R01 CA214043. ABF and MAC were also supported in part by the NIH NCI grant U54 CA163072. DHH was also supported in part by a 2018 Burroughs Wellcome Fund Physician-Scientist Institutional Award to Vanderbilt University [ID: 1018894]. These funding sources had no role in study design; collection, analysis, or interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

Financiadores	Número del financiador
NCI/NIH	R01 CA214043, U54 CA163072
National Institutes of Health (NIH)
Burroughs Wellcome Fund
Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center	1018894
National Institute on Minority Health and Disparities	U54MD010722
Institut National Du Cancer	U54 MD010722

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Epidemiology
Oncology
Cancer Research

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10.1016/j.canep.2021.102013

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@article{970783f68103460ead5e1ad30c20e7ba,

title = "Increasing Area Deprivation Index negatively impacts ovarian cancer survival",

abstract = "Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas{\textregistered}. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 \% or 10 \% greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.",

keywords = "Ovarian neoplasms, Prognosis, Socioeconomic factors, Survival",

author = "Hufnagel, \{Demetra H.\} and Dineo Khabele and Yull, \{Fiona E.\} and Hull, \{Pamela C.\} and Joellen Schildkraut and Crispens, \{Marta A.\} and Alicia Beeghly-Fadiel",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = oct,

doi = "10.1016/j.canep.2021.102013",

language = "English",

volume = "74",

}

TY - JOUR

T1 - Increasing Area Deprivation Index negatively impacts ovarian cancer survival

AU - Hufnagel, Demetra H.

AU - Khabele, Dineo

AU - Yull, Fiona E.

AU - Hull, Pamela C.

AU - Schildkraut, Joellen

AU - Crispens, Marta A.

AU - Beeghly-Fadiel, Alicia

PY - 2021/10

Y1 - 2021/10

N2 - Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.

AB - Introduction: While individual-level measures of socioeconomic status have been well-studied in relation to ovarian cancer survival, no studies to date have examined both state and national-level Area Deprivation Indices (ADIs), which incorporate neighborhood affluence and resources. Methods: We abstracted clinical data from medical records for ovarian cancer cases from the Vanderbilt University Medical Center and obtained ADIs from the Neighborhood Atlas®. Associations with clinical characteristics were assessed with Spearman correlations and Kruskal-Wallis tests; associations with progression-free survival (PFS) and overall survival (OS) were assessed with Cox proportional-hazards regression. Results: Among 184 cases, state and national ADIs were highly correlated, but not related to any cancer characteristics. In multivariable adjusted regression models, both were significantly associated with OS; each decile increase in state or national ADI corresponded to a 9 % or 10 % greater risk of death, respectively. Conclusions: Increasing area-level deprivation may negatively impact ovarian cancer survival.

KW - Ovarian neoplasms

KW - Prognosis

KW - Socioeconomic factors

KW - Survival

UR - https://www.scopus.com/pages/publications/85113316903

UR - https://www.scopus.com/pages/publications/85113316903#tab=citedBy

U2 - 10.1016/j.canep.2021.102013

DO - 10.1016/j.canep.2021.102013

M3 - Article

C2 - 34438316

AN - SCOPUS:85113316903

SN - 1877-7821

VL - 74

JO - Cancer Epidemiology

JF - Cancer Epidemiology

M1 - 102013

ER -

Increasing Area Deprivation Index negatively impacts ovarian cancer survival

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Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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