Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells

Chad A. Dickey; Dirson D. De Mesquita; Dave Morgan; Keith R. Pennypacker

doi:10.1016/j.neulet.2004.04.089

Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells

Chad A. Dickey
, Dirson D. De Mesquita
, Dave Morgan
, Keith R. Pennypacker

Producción científica: Article › revisión exhaustiva

21 Citas (Scopus)

Resumen

Activation of several immediate early genes (IEGs) is crucial for long-term memory formation in vivo. In vitro methods of inducing these genes have not been investigated extensively. Here we present data demonstrating that application of the neurotrophin, nerve growth factor (NGF), to both rat primary neuronal cultures and differentiated mouse neuroblastoma 2A (N2A) cultures reliably induces expression of several IEGs, including Zif268, Nur77 and Arc, each of which have been linked to memory consolidation. These findings provide an in vitro model in which to test other agents that might modulate the induction of memory-associated genes.

Idioma original	English
Páginas (desde-hasta)	10-14
Número de páginas	5
Publicación	Neuroscience Letters
Volumen	366
N.º	1
DOI	https://doi.org/10.1016/j.neulet.2004.04.089
Estado	Published - ago 5 2004

Nota bibliográfica

Funding Information:
This work was supported by grant nos. AG15490, AG18478, and NS039141 from NIH.

Financiación

This work was supported by grant nos. AG15490, AG18478, and NS039141 from NIH.

Financiadores	Número del financiador
National Institutes of Health (NIH)
National Institute of Neurological Disorders and Stroke	R01NS039141

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2004.04.089

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title = "Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells",

abstract = "Activation of several immediate early genes (IEGs) is crucial for long-term memory formation in vivo. In vitro methods of inducing these genes have not been investigated extensively. Here we present data demonstrating that application of the neurotrophin, nerve growth factor (NGF), to both rat primary neuronal cultures and differentiated mouse neuroblastoma 2A (N2A) cultures reliably induces expression of several IEGs, including Zif268, Nur77 and Arc, each of which have been linked to memory consolidation. These findings provide an in vitro model in which to test other agents that might modulate the induction of memory-associated genes.",

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T1 - Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells

AU - Dickey, Chad A.

AU - De Mesquita, Dirson D.

AU - Morgan, Dave

AU - Pennypacker, Keith R.

N1 - Funding Information: This work was supported by grant nos. AG15490, AG18478, and NS039141 from NIH.

PY - 2004/8/5

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AB - Activation of several immediate early genes (IEGs) is crucial for long-term memory formation in vivo. In vitro methods of inducing these genes have not been investigated extensively. Here we present data demonstrating that application of the neurotrophin, nerve growth factor (NGF), to both rat primary neuronal cultures and differentiated mouse neuroblastoma 2A (N2A) cultures reliably induces expression of several IEGs, including Zif268, Nur77 and Arc, each of which have been linked to memory consolidation. These findings provide an in vitro model in which to test other agents that might modulate the induction of memory-associated genes.

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KW - Immediate-early genes

KW - Induction

KW - Memory

KW - Neurotrophins

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Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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