Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)

Brittany L. Carpenter; Min Chen; Teresa Knifley; Kelley A. Davis; Susan M.W. Harrison; Rachel L. Stewart; Kathleen L. O'Connor

doi:10.1074/jbc.M115.686873

Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)

Brittany L. Carpenter
, Min Chen
, Teresa Knifley
, Kelley A. Davis
, Susan M.W. Harrison
, Rachel L. Stewart
, Kathleen L. O'Connor

Producción científica: Article › revisión exhaustiva

31 Citas (Scopus)

Resumen

Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.

Idioma original	English
Páginas (desde-hasta)	27228-27238
Número de páginas	11
Publicación	Journal of Biological Chemistry
Volumen	290
N.º	45
DOI	https://doi.org/10.1074/jbc.M115.686873
Estado	Published - nov 6 2015

Nota bibliográfica

Publisher Copyright:
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Financiación

Financiadores	Número del financiador
National Institutes of Health (NIH)	R01 CA109136, T32 CA160003, T32 CA165990, IRG-85-001-25
National Childhood Cancer Registry – National Cancer Institute	T32CA160003
National Childhood Cancer Registry – National Cancer Institute

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M115.686873

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Carpenter, B. L., Chen, M., Knifley, T., Davis, K. A., Harrison, S. M. W., Stewart, R. L., & O'Connor, K. L. (2015). Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF). Journal of Biological Chemistry, 290(45), 27228-27238. https://doi.org/10.1074/jbc.M115.686873

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title = "Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)",

abstract = "Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.",

author = "Carpenter, \{Brittany L.\} and Min Chen and Teresa Knifley and Davis, \{Kelley A.\} and Harrison, \{Susan M.W.\} and Stewart, \{Rachel L.\} and O'Connor, \{Kathleen L.\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

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day = "6",

doi = "10.1074/jbc.M115.686873",

language = "English",

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T1 - Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)

AU - Carpenter, Brittany L.

AU - Chen, Min

AU - Knifley, Teresa

AU - Davis, Kelley A.

AU - Harrison, Susan M.W.

AU - Stewart, Rachel L.

AU - O'Connor, Kathleen L.

PY - 2015/11/6

Y1 - 2015/11/6

N2 - Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.

AB - Background: Integrin α6β4 is overexpressed in pancreatic cancer and enhances invasion. Results: Integrin α6β4 coordinately up-regulates AREG, EREG, and MMP1 through DNA demethylation and NFAT5 that in turn enhances HGF-mediated invasion. Conclusion: Integrin α6β4 stimulates HGF-dependent invasion through autocrine EGFR signaling. Significance: HGF-stimulated invasion is dependent on autocrine EGFR signaling, thus implicating why EGFR inhibitors are effective in a complex tumor micro environment.

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DO - 10.1074/jbc.M115.686873

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AN - SCOPUS:84946605397

SN - 0021-9258

VL - 290

SP - 27228

EP - 27238

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 45

ER -

Integrin α6β4 promotes autocrine Epidermal Growth Factor Receptor (EGFR) signaling to stimulate migration and invasion toward hepatocyte growth factor (HGF)

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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