Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells

Eva Müller; Reinhold Munker; Rolf Issels; Wolfgang Wilmanns

doi:10.1016/0145-2126(93)90128-8

Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells

Eva Müller
, Reinhold Munker
, Rolf Issels
, Wolfgang Wilmanns

Producción científica: Article › revisión exhaustiva

11 Citas (Scopus)

Resumen

We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blasts and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.

Idioma original	English
Páginas (desde-hasta)	523-526
Número de páginas	4
Publicación	Leukemia Research
Volumen	17
N.º	6
DOI	https://doi.org/10.1016/0145-2126(93)90128-8
Estado	Published - jun 1993

Financiación

Acknowledgements--We thank Ms S. Pander for expert technical assistance, Ms A. Schaaf for editorial help, Dr L. Heine for providing us with the monoclonal antibody 8F7 and the W. Sander Stiftung for financial support.

Financiadores
W. Sander Stiftung

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

Acceder al documento

10.1016/0145-2126(93)90128-8

Otros archivos y enlaces

Citar esto

@article{93f3115ed9da423cb8459bb4326c85f5,

title = "Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells",

abstract = "We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blasts and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.",

keywords = "heat shock proteins, human leukemia cells, Tumor necrosis factor",

author = "Eva M{\"u}ller and Reinhold Munker and Rolf Issels and Wolfgang Wilmanns",

year = "1993",

month = jun,

doi = "10.1016/0145-2126(93)90128-8",

language = "English",

volume = "17",

pages = "523--526",

number = "6",

}

TY - JOUR

T1 - Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells

AU - Müller, Eva

AU - Munker, Reinhold

AU - Issels, Rolf

AU - Wilmanns, Wolfgang

PY - 1993/6

Y1 - 1993/6

N2 - We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blasts and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.

AB - We confirm here by immunoblotting that a cell line resistant to clonal inhibition from tumor necrosis factor (K562) expresses high levels of HSP 70, whereas two sensitive cell lines (HL60 blasts and EM3) express low levels. When sensitive cell lines are exposed to tumor necrosis factor, HSP 70 is not generally induced; when tumor necrosis factor is removed, however, HSP 70 is transiently induced. In five bone marrow samples from patients, generally low levels of HSP 70 were detected.

KW - heat shock proteins

KW - human leukemia cells

KW - Tumor necrosis factor

UR - https://www.scopus.com/pages/publications/0027211998

UR - https://www.scopus.com/pages/publications/0027211998#tab=citedBy

U2 - 10.1016/0145-2126(93)90128-8

DO - 10.1016/0145-2126(93)90128-8

M3 - Article

C2 - 8505849

AN - SCOPUS:0027211998

SN - 0145-2126

VL - 17

SP - 523

EP - 526

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Interaction between tumor necrosis factor-α and HSP 70 in human leukemia cells

Resumen

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto