Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Ting Kuang Niu; Yan Cheng; Xingcong Ren; Jin Ming Yang

doi:10.1016/j.febslet.2010.07.018

Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Ting Kuang Niu, Yan Cheng, Xingcong Ren, Jin Ming Yang

Producción científica: Article › revisión exhaustiva

67 Citas (Scopus)

Resumen

We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

Idioma original	English
Páginas (desde-hasta)	3519-3524
Número de páginas	6
Publicación	FEBS Letters
Volumen	584
N.º	16
DOI	https://doi.org/10.1016/j.febslet.2010.07.018
Estado	Published - ago 2010

Nota bibliográfica

Funding Information:
We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

Financiación

We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

Financiadores	Número del financiador
National Childhood Cancer Registry – National Cancer Institute	R01CA 135038, R01CA066077

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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title = "Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis",

abstract = "We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.",

keywords = "Apoptosis, Autophagy, Beclin 1, Survivin, Tumor necrosis factor-related apoptosis-inducing ligand",

author = "Niu, \{Ting Kuang\} and Yan Cheng and Xingcong Ren and Yang, \{Jin Ming\}",

note = "Funding Information: We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .",

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AU - Niu, Ting Kuang

AU - Cheng, Yan

AU - Ren, Xingcong

AU - Yang, Jin Ming

N1 - Funding Information: We are grateful to Dr. Dario Altieri (University of Massachusetts Medical School) for providing us with the human survivin expression vector. This work was supported by grants from the National Cancer Institute R01CA 135038 and R01CA 66077 .

PY - 2010/8

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N2 - We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

AB - We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis.

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KW - Autophagy

KW - Beclin 1

KW - Survivin

KW - Tumor necrosis factor-related apoptosis-inducing ligand

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Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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