TY - JOUR
T1 - Interaction of tacrine and velnacrine with neocortical synaptosomal membranes
T2 - Relevance to Alzheimer's disease
AU - Butterfield, D. Allan
AU - Hensley, Kenneth
AU - Hall, Nathan
AU - Umhauer, Sandra
AU - Carney, John
PY - 1993/9
Y1 - 1993/9
N2 - The acridine-based, potential Alzheimer's disease therapeutic agents, tacrine and velnacrine, were incubated with rat or gerbil neocortical synaptosomal membranes. Electron paramagnetic resonance employing a protein-specific spin label was used to monitor this interaction. Analogous to their effects in erythrocyte membranes [Butterfield and Rangachari (1992) Biochem. Biophys. Res. Commun. 185: 596-603], in the present studies both agents decreased segmental motion of spin labeled synaptosomal membrane proteins, consistent with increased cytoskeletal protein-protein interactions (0.001
AB - The acridine-based, potential Alzheimer's disease therapeutic agents, tacrine and velnacrine, were incubated with rat or gerbil neocortical synaptosomal membranes. Electron paramagnetic resonance employing a protein-specific spin label was used to monitor this interaction. Analogous to their effects in erythrocyte membranes [Butterfield and Rangachari (1992) Biochem. Biophys. Res. Commun. 185: 596-603], in the present studies both agents decreased segmental motion of spin labeled synaptosomal membrane proteins, consistent with increased cytoskeletal protein-protein interactions (0.001
KW - Alzheimer's disease
KW - Synaptosomal membranes
KW - cytoskeletal protein-protein interactions
KW - tacrine
KW - velnacrine
UR - https://www.scopus.com/pages/publications/0027219284
UR - https://www.scopus.com/pages/publications/0027219284#tab=citedBy
U2 - 10.1007/BF00966758
DO - 10.1007/BF00966758
M3 - Article
C2 - 8232727
AN - SCOPUS:0027219284
SN - 0364-3190
VL - 18
SP - 989
EP - 994
JO - Neurochemical Research
JF - Neurochemical Research
IS - 9
ER -