Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

Khaled A. Shaaban; Mohamed Shaaban; Iris Grün-Wollny; Armin Maier; Heinz H. Fiebig; Hartmut Laatsch

doi:10.1021/np070196h

Julichrome Q₆ glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.

Khaled A. Shaaban
, Mohamed Shaaban
, Iris Grün-Wollny
, Armin Maier
, Heinz H. Fiebig
, Hartmut Laatsch

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

21 Citas (Scopus)

Resumen

The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q ₆ glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q_1.2 (7a), Q_1.5 (7b), and Q_3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

Idioma original	English
Páginas (desde-hasta)	1545-1550
Número de páginas	6
Publicación	Journal of Natural Products
Volumen	70
N.º	10
DOI	https://doi.org/10.1021/np070196h
Estado	Published - oct 2007

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Life below water

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Acceder al documento

10.1021/np070196h

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title = "Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.",

abstract = "The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.",

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doi = "10.1021/np070196h",

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AU - Shaaban, Khaled A.

AU - Shaaban, Mohamed

AU - Grün-Wollny, Iris

AU - Maier, Armin

AU - Fiebig, Heinz H.

AU - Laatsch, Hartmut

PY - 2007/10

Y1 - 2007/10

N2 - The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

AB - The terrestrial Streptomyces sp. isolate GW6225 afforded julichrome Q 6 glucuronide (9), the first monomeric member of the julimycin-B complex, and additionally the julichromes Q1.2 (7a), Q1.5 (7b), and Q3.5 (8), which were fully characterized by 2D NMR spectra. Additional new microbial compounds were 4-acetylchrysophanol (6a) and N-phenyl-β-naphthylamine (10). The isomeric N-phenyl-α-naphthylamine (11) was found in the marine Streptomyces sp. B8335 and was also characterized. The high antibiotic activity of Streptomyces sp. GW6225 extracts was probably due to the thiazolyl cyclopeptide nosiheptide.

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