Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Leon M. Tai; Tina Bilousova; Lisa Jungbauer; Stephen K. Roeske; Katherine L. Youmans; Chunjiang Yu; Wayne W. Poon; Lindsey B. Cornwell; Carol A. Miller; Harry V. Vinters; Linda J. Van Eldik; David W. Fardo; Steve Estus; Guojun Bu; Karen Hoppens Gylys; Mary Jo LaDu

doi:10.1074/jbc.M112.442103

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Leon M. Tai
, Tina Bilousova
, Lisa Jungbauer
, Stephen K. Roeske
, Katherine L. Youmans
, Chunjiang Yu
, Wayne W. Poon
, Lindsey B. Cornwell
, Carol A. Miller
, Harry V. Vinters
, Linda J. Van Eldik
, David W. Fardo
, Steve Estus
, Guojun Bu
, Karen Hoppens Gylys
, Mary Jo LaDu

Producción científica: Article › revisión exhaustiva

142 Citas (Scopus)

Resumen

Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.

Idioma original	English
Páginas (desde-hasta)	5914-5926
Número de páginas	13
Publicación	Journal of Biological Chemistry
Volumen	288
N.º	8
DOI	https://doi.org/10.1074/jbc.M112.442103
Estado	Published - feb 22 2013

Financiación

Financiadores	Número del financiador
U.S. Department of Health & Human Services \| NIH \| National Institute on Aging (U.S. National Institute on Aging)	R01AG046205

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.442103

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Tai, L. M., Bilousova, T., Jungbauer, L., Roeske, S. K., Youmans, K. L., Yu, C., Poon, W. W., Cornwell, L. B., Miller, C. A., Vinters, H. V., Van Eldik, L. J., Fardo, D. W., Estus, S., Bu, G., Gylys, K. H., & LaDu, M. J. (2013). Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples. Journal of Biological Chemistry, 288(8), 5914-5926. https://doi.org/10.1074/jbc.M112.442103

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title = "Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples",

abstract = "Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.",

author = "Tai, \{Leon M.\} and Tina Bilousova and Lisa Jungbauer and Roeske, \{Stephen K.\} and Youmans, \{Katherine L.\} and Chunjiang Yu and Poon, \{Wayne W.\} and Cornwell, \{Lindsey B.\} and Miller, \{Carol A.\} and Vinters, \{Harry V.\} and \{Van Eldik\}, \{Linda J.\} and Fardo, \{David W.\} and Steve Estus and Guojun Bu and Gylys, \{Karen Hoppens\} and LaDu, \{Mary Jo\}",

year = "2013",

month = feb,

day = "22",

doi = "10.1074/jbc.M112.442103",

language = "English",

volume = "288",

pages = "5914--5926",

number = "8",

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Tai, LM, Bilousova, T, Jungbauer, L, Roeske, SK, Youmans, KL, Yu, C, Poon, WW, Cornwell, LB, Miller, CA, Vinters, HV, Van Eldik, LJ , Fardo, DW, Estus, S, Bu, G, Gylys, KH & LaDu, MJ 2013, 'Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples', Journal of Biological Chemistry, vol. 288, n.º 8, pp. 5914-5926. https://doi.org/10.1074/jbc.M112.442103

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples. / Tai, Leon M.; Bilousova, Tina; Jungbauer, Lisa et al.
En: Journal of Biological Chemistry, Vol. 288, N.º 8, 22.02.2013, p. 5914-5926.

Producción científica: Article › revisión exhaustiva

TY - JOUR

T1 - Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

AU - Tai, Leon M.

AU - Bilousova, Tina

AU - Jungbauer, Lisa

AU - Roeske, Stephen K.

AU - Youmans, Katherine L.

AU - Yu, Chunjiang

AU - Poon, Wayne W.

AU - Cornwell, Lindsey B.

AU - Miller, Carol A.

AU - Vinters, Harry V.

AU - Van Eldik, Linda J.

AU - Fardo, David W.

AU - Estus, Steve

AU - Bu, Guojun

AU - Gylys, Karen Hoppens

AU - LaDu, Mary Jo

PY - 2013/2/22

Y1 - 2013/2/22

N2 - Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.

AB - Background: An ELISA was developed to determine the role of apoE/Aβ on soluble Aβ accumulation. Results: In AD transgenic mouse brain and human synaptosomes and CSF, levels of soluble apoE/Aβ are lower and oligomeric Aβ levels are higher with APOE4 and AD. Conclusion: Isoform-specific apoE/Aβ levels modulate soluble oligomeric Aβ levels. Significance: ApoE/Aβ and oligomeric Aβ represent a mechanistic approach to AD biomarkers.

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U2 - 10.1074/jbc.M112.442103

DO - 10.1074/jbc.M112.442103

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AN - SCOPUS:84874334207

SN - 0021-9258

VL - 288

SP - 5914

EP - 5926

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 8

ER -

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and alzheimer disease in a transgenic mouse model and human samples

Resumen

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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