Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter; David K. Heidary; Brock S. Howerton; Sean Parkin; Edith C. Glazer

doi:10.1039/c2cc33359g

Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

Erin Wachter
, David K. Heidary
, Brock S. Howerton
, Sean Parkin
, Edith C. Glazer

Chemistry

Producción científica: Article › revisión exhaustiva

297 Citas (Scopus)

Resumen

Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

Idioma original	English
Páginas (desde-hasta)	9649-9651
Número de páginas	3
Publicación	Chemical Communications
Volumen	48
N.º	77
DOI	https://doi.org/10.1039/c2cc33359g
Estado	Published - ago 29 2012

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ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.",

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AU - Wachter, Erin

AU - Heidary, David K.

AU - Howerton, Brock S.

AU - Parkin, Sean

AU - Glazer, Edith C.

PY - 2012/8/29

Y1 - 2012/8/29

N2 - Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

AB - Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.

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UR - https://www.scopus.com/pages/publications/84865677118#tab=citedBy

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Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window

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