Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Edward T. Ryan; Emily A. Bridges; Thomas I. Crean; Kaniz Gausia; Jena D. Hamadani; Ayesha Aziz; Sarah Hawkes; Monira Begum; Jozef Bogaerts; Shah M. Faruque; Mohammed Abdus Salam; George J. Fuchs; Stephen B. Calderwood

doi:10.1086/322807

Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Edward T. Ryan
, Emily A. Bridges
, Thomas I. Crean
, Kaniz Gausia
, Jena D. Hamadani
, Ayesha Aziz
, Sarah Hawkes
, Monira Begum
, Jozef Bogaerts
, Shah M. Faruque
, Mohammed Abdus Salam
, George J. Fuchs
, Stephen B. Calderwood

Producción científica: Article › revisión exhaustiva

2 Citas (Scopus)

Resumen

To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

Idioma original	English
Páginas (desde-hasta)	643-647
Número de páginas	5
Publicación	Journal of Infectious Diseases
Volumen	184
N.º	5
DOI	https://doi.org/10.1086/322807
Estado	Published - sept 1 2001

Nota bibliográfica

Funding Information:
Financial support: Warren-Whitman-Richardson Traveling Fellowship, Harvard Medical School (to E.T.R.); Aaron Diamond Fellowship in Medicine and Human Rights, Center for the Study of Society and Medicine, Columbia University College of Physicians and Surgeons (to E.T.R.); and National Institutes of Health (AI-01332 to E.T.R.; AI-40725 to S.B.C. and E.T.R.; and HD-39165 to S.B.C. and E.T.R.). The ICDDR, B: Centre for Health and Population Research is supported by countries that share its concern for health problems in developing countries. Current donors providing unrestricted support include aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Japan, the Kingdom of Saudi Arabia, The Netherlands, Sweden, Sri Lanka, Switzerland, the United Kingdom, and the United States and international organizations, including the United Nations Children’s Fund.

Financiación

Financial support: Warren-Whitman-Richardson Traveling Fellowship, Harvard Medical School (to E.T.R.); Aaron Diamond Fellowship in Medicine and Human Rights, Center for the Study of Society and Medicine, Columbia University College of Physicians and Surgeons (to E.T.R.); and National Institutes of Health (AI-01332 to E.T.R.; AI-40725 to S.B.C. and E.T.R.; and HD-39165 to S.B.C. and E.T.R.). The ICDDR, B: Centre for Health and Population Research is supported by countries that share its concern for health problems in developing countries. Current donors providing unrestricted support include aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Japan, the Kingdom of Saudi Arabia, The Netherlands, Sweden, Sri Lanka, Switzerland, the United Kingdom, and the United States and international organizations, including the United Nations Children’s Fund.

Financiadores	Número del financiador
Columbia University College of Physicians and Surgeons
National Institutes of Health (NIH)	AI-01332, HD-39165
National Institutes of Health (NIH)
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases	R01AI040725
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases
Harvard Medical School

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

General Medicine

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10.1086/322807

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Ryan, E. T., Bridges, E. A., Crean, T. I., Gausia, K., Hamadani, J. D., Aziz, A., Hawkes, S., Begum, M., Bogaerts, J., Faruque, S. M., Salam, M. A., Fuchs, G. J., & Calderwood, S. B. (2001). Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera. Journal of Infectious Diseases, 184(5), 643-647. https://doi.org/10.1086/322807

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title = "Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera",

abstract = "To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.",

author = "Ryan, \{Edward T.\} and Bridges, \{Emily A.\} and Crean, \{Thomas I.\} and Kaniz Gausia and Hamadani, \{Jena D.\} and Ayesha Aziz and Sarah Hawkes and Monira Begum and Jozef Bogaerts and Faruque, \{Shah M.\} and Salam, \{Mohammed Abdus\} and Fuchs, \{George J.\} and Calderwood, \{Stephen B.\}",

note = "Funding Information: Financial support: Warren-Whitman-Richardson Traveling Fellowship, Harvard Medical School (to E.T.R.); Aaron Diamond Fellowship in Medicine and Human Rights, Center for the Study of Society and Medicine, Columbia University College of Physicians and Surgeons (to E.T.R.); and National Institutes of Health (AI-01332 to E.T.R.; AI-40725 to S.B.C. and E.T.R.; and HD-39165 to S.B.C. and E.T.R.). The ICDDR, B: Centre for Health and Population Research is supported by countries that share its concern for health problems in developing countries. Current donors providing unrestricted support include aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Japan, the Kingdom of Saudi Arabia, The Netherlands, Sweden, Sri Lanka, Switzerland, the United Kingdom, and the United States and international organizations, including the United Nations Children{\textquoteright}s Fund.",

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language = "English",

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AU - Bridges, Emily A.

AU - Crean, Thomas I.

AU - Gausia, Kaniz

AU - Hamadani, Jena D.

AU - Aziz, Ayesha

AU - Hawkes, Sarah

AU - Begum, Monira

AU - Bogaerts, Jozef

AU - Faruque, Shah M.

AU - Salam, Mohammed Abdus

AU - Fuchs, George J.

AU - Calderwood, Stephen B.

N1 - Funding Information: Financial support: Warren-Whitman-Richardson Traveling Fellowship, Harvard Medical School (to E.T.R.); Aaron Diamond Fellowship in Medicine and Human Rights, Center for the Study of Society and Medicine, Columbia University College of Physicians and Surgeons (to E.T.R.); and National Institutes of Health (AI-01332 to E.T.R.; AI-40725 to S.B.C. and E.T.R.; and HD-39165 to S.B.C. and E.T.R.). The ICDDR, B: Centre for Health and Population Research is supported by countries that share its concern for health problems in developing countries. Current donors providing unrestricted support include aid agencies of the governments of Australia, Bangladesh, Belgium, Canada, Japan, the Kingdom of Saudi Arabia, The Netherlands, Sweden, Sri Lanka, Switzerland, the United Kingdom, and the United States and international organizations, including the United Nations Children’s Fund.

PY - 2001/9/1

Y1 - 2001/9/1

N2 - To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

AB - To investigate whether intestinal presentation of an antigen by Vibrio cholerae, a noninvasive organism, could induce an anatomically distant mucosal immune response in reproductive tract tissues, the endocervical immune responses of women in Bangladesh were evaluated after cholera. Endocervical secretions were analyzed for secretory IgA (sIgA) antibody against the B subunit of cholera toxin (CtxB) in 9 women with cholera and 8 women with diarrhea caused by neither V. cholerae nor heat labile enterotoxin-producing Escherichia coli. Women infected with V. cholerae developed significant sIgA anti-CtxB responses in endocervical samples (P .02). Antibody subtype analysis of endocervical IgA was consistent with local mucosal production (P .001). Women with cholera did not develop sIgA anti-CtxB responses in serum. The ability to generate specific mucosal immune responses in reproductive tract tissues after intestinal presentation of antigen could facilitate development of vaccines effective against reproductive tract pathogens.

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AN - SCOPUS:0035450272

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Local production of anti-Vibrio cholerae mucosal antibody in reproductive tract tissues after cholera

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

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