Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats

Changiz Geula; Patrick A. Jarvie; Thomas C. Logan; John T. Slevin

doi:10.1016/0006-8993(88)91528-4

Long-term enhancement of K⁺-evoked release of l-glutamate in entorhinal kindled rats

Changiz Geula
, Patrick A. Jarvie
, Thomas C. Logan
, John T. Slevin

Producción científica: Article › revisión exhaustiva

59 Citas (Scopus)

Resumen

Kainic acid- and K⁺-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K⁺-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

Idioma original	English
Páginas (desde-hasta)	368-372
Número de páginas	5
Publicación	Brain Research
Volumen	442
N.º	2
DOI	https://doi.org/10.1016/0006-8993(88)91528-4
Estado	Published - mar 1 1988

Nota bibliográfica

Funding Information:
The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

Financiación

The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

Financiadores	Número del financiador
Veterans Administration Medical Research Service
National Institute on Aging	T32AG000084, 1 T32 AG00084-01A1
National Institute on Aging

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)91528-4

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title = "Long-term enhancement of K+-evoked release of l-glutamate in entorhinal kindled rats",

abstract = "Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.",

keywords = "Amino acid, Glutamate, Hippocampus, Kainic acid, Kindling, Neurotransmitter release",

author = "Changiz Geula and Jarvie, \{Patrick A.\} and Logan, \{Thomas C.\} and Slevin, \{John T.\}",

note = "Funding Information: The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.",

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AU - Logan, Thomas C.

AU - Slevin, John T.

N1 - Funding Information: The authors thank Lindley P. Wemmer and Ramona M. Alcala for their expert technical assistance and Renee Eikins for typing the manuscript. This research was supported by the Veterans Administration Research Service, the NIA (1 T32 AG00084-01A1), and the Bertha LeBus Educational and Cha-litable Trust. J.T.S. is the recipient of a Teacher-ln-vestigator Development Award (NS00732) from the NINCDS.

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N2 - Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

AB - Kainic acid- and K+-evoked in vitro release of endogenous amino acids from hippocampal slices were measured in rats kindled by entorhinal electrical stimulation. One month after completion of kindling, K+-evoked release of glutamate from hippocampal slices ipsilateral to the stimulus site was consistently greater than from both the contralateral hippocampus from kindled animals and all hippocampi of electroshock and sham-surgery control groups. Enhanced hippocampal neurotransmitter glutamate release may be involved in the permanent effects of electrical kindling.

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KW - Glutamate

KW - Hippocampus

KW - Kainic acid

KW - Kindling

KW - Neurotransmitter release

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