Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release

Nitin S. Satarkar; J. Zach Hilt

doi:10.1016/j.jconrel.2008.06.008

Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release

Nitin S. Satarkar
, J. Zach Hilt

Producción científica: Article › revisión exhaustiva

474 Citas (Scopus)

Resumen

Hydrogel nanocomposites are novel macromolecular biomaterials that promise to impact various applications in medical and pharmaceutical fields. In this paper, magnetic nanocomposites of temperature responsive hydrogels were used to illustrate remote controlled (RC) drug delivery. A high frequency alternating magnetic field (AMF) was used to trigger the on-demand pulsatile drug release from the nanocomposites. Nanocomposites were synthesized by incorporation of superparamagnetic Fe₃O₄ particles in negative temperature sensitive poly (N-isopropylacrylamide) hydrogels. Pulses of AMF were applied to the nanocomposites and the kinetics of collapse and recovery were characterized. Application of AMF resulted in uniform heating within the nanocomposites leading to accelerated collapse and squeezing out large amounts of imbibed drug (release at a faster rate). Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF.

Idioma original	English
Páginas (desde-hasta)	246-251
Número de páginas	6
Publicación	Journal of Controlled Release
Volumen	130
N.º	3
DOI	https://doi.org/10.1016/j.jconrel.2008.06.008
Estado	Published - sept 24 2008

Nota bibliográfica

Funding Information:
This material is based in part on work supported by the National Science Foundation under grant numbers ECS-0508254 (NSF NER) and CTS-0609117 (NSF NIRT). The authors thank Dr. Dipti Biswal for assistance with acquisition of SEM images.

Financiación

This material is based in part on work supported by the National Science Foundation under grant numbers ECS-0508254 (NSF NER) and CTS-0609117 (NSF NIRT). The authors thank Dr. Dipti Biswal for assistance with acquisition of SEM images.

Financiadores	Número del financiador
NSF NER	CTS-0609117
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China	ECS-0508254
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2008.06.008

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title = "Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release",

abstract = "Hydrogel nanocomposites are novel macromolecular biomaterials that promise to impact various applications in medical and pharmaceutical fields. In this paper, magnetic nanocomposites of temperature responsive hydrogels were used to illustrate remote controlled (RC) drug delivery. A high frequency alternating magnetic field (AMF) was used to trigger the on-demand pulsatile drug release from the nanocomposites. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature sensitive poly (N-isopropylacrylamide) hydrogels. Pulses of AMF were applied to the nanocomposites and the kinetics of collapse and recovery were characterized. Application of AMF resulted in uniform heating within the nanocomposites leading to accelerated collapse and squeezing out large amounts of imbibed drug (release at a faster rate). Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF.",

keywords = "Composite, Drug delivery, Hydrogel, Magnetic, Remote control",

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AU - Hilt, J. Zach

N1 - Funding Information: This material is based in part on work supported by the National Science Foundation under grant numbers ECS-0508254 (NSF NER) and CTS-0609117 (NSF NIRT). The authors thank Dr. Dipti Biswal for assistance with acquisition of SEM images.

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N2 - Hydrogel nanocomposites are novel macromolecular biomaterials that promise to impact various applications in medical and pharmaceutical fields. In this paper, magnetic nanocomposites of temperature responsive hydrogels were used to illustrate remote controlled (RC) drug delivery. A high frequency alternating magnetic field (AMF) was used to trigger the on-demand pulsatile drug release from the nanocomposites. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature sensitive poly (N-isopropylacrylamide) hydrogels. Pulses of AMF were applied to the nanocomposites and the kinetics of collapse and recovery were characterized. Application of AMF resulted in uniform heating within the nanocomposites leading to accelerated collapse and squeezing out large amounts of imbibed drug (release at a faster rate). Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF.

AB - Hydrogel nanocomposites are novel macromolecular biomaterials that promise to impact various applications in medical and pharmaceutical fields. In this paper, magnetic nanocomposites of temperature responsive hydrogels were used to illustrate remote controlled (RC) drug delivery. A high frequency alternating magnetic field (AMF) was used to trigger the on-demand pulsatile drug release from the nanocomposites. Nanocomposites were synthesized by incorporation of superparamagnetic Fe3O4 particles in negative temperature sensitive poly (N-isopropylacrylamide) hydrogels. Pulses of AMF were applied to the nanocomposites and the kinetics of collapse and recovery were characterized. Application of AMF resulted in uniform heating within the nanocomposites leading to accelerated collapse and squeezing out large amounts of imbibed drug (release at a faster rate). Remote controlled pulsatile drug release was characterized for different drugs as well as for different ON-OFF durations of the AMF.

KW - Composite

KW - Drug delivery

KW - Hydrogel

KW - Magnetic

KW - Remote control

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SN - 0168-3659

VL - 130

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EP - 251

JO - Journal of Controlled Release

JF - Journal of Controlled Release

IS - 3

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Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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