TY - JOUR
T1 - Major Publications in the Critical Care Pharmacotherapy Literature
T2 - 2021
AU - Wieruszewski, Patrick M.
AU - Brickett, Laura M.
AU - Dayal, Lokesh
AU - Egan, Ashley M.
AU - Khanna, Ashish K.
AU - Lemieux, Steven M.
AU - Mukkera, Satyanarayana R.
AU - Patel, Jaimini S.
AU - Reichert, Michael J.
AU - Reynolds, Tessa R.
AU - Sen, Parijat
AU - Thornton, Nathaniel M.
AU - Turpin, Gavin M.
AU - Winter, Jessica B.
AU - Bissell, Brittany D.
N1 - Publisher Copyright:
© 2022 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
PY - 2022/12/14
Y1 - 2022/12/14
N2 - OBJECTIVES: To summarize the most impactful articles relevant to the pharmacotherapy of critically ill adult patients published in 2021. DATA SOURCE: PubMed/MEDLINE. STUDY SELECTION: Randomized controlled trials, prospective studies, or systematic review/meta-analyses of adult critical care patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2021, and December 31, 2021. DATA EXTRACTION: Candidate articles were organized by clinical domain based on the emerging themes from all studies. A modified Delphi process was applied to obtain consensus on the most impactful publication within each clinical domain based on overall contribution to scientific knowledge and novelty to the literature. DATA SYNTHESIS: The search revealed 830 articles, of which 766 were excluded leaving 64 candidate articles for the Delphi process. These 64 articles were organized by clinical domain including: emergency/neurology, cardiopulmonary, nephrology/fluids, infectious diseases, metabolic, immunomodulation, and nutrition/gastroenterology. Each domain required the a priori defined three Delphi rounds. The resultant most impactful articles from each domain included five randomized controlled trials and two systematic review/meta-analyses. Topics studied included sedation during mechanical ventilation, anticoagulation in COVID-19, extended infusion beta-lactams, interleukin-6 antagonists in COVID-19, balanced crystalloid resuscitation, vitamin C/thiamine/hydrocortisone in sepsis, and promotility agents during enteral feeding. CONCLUSIONS: This synoptic review provides a summary and perspective of the most impactful articles relevant to the pharmacotherapy of critically ill adults published in 2021.
AB - OBJECTIVES: To summarize the most impactful articles relevant to the pharmacotherapy of critically ill adult patients published in 2021. DATA SOURCE: PubMed/MEDLINE. STUDY SELECTION: Randomized controlled trials, prospective studies, or systematic review/meta-analyses of adult critical care patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints published between January 1, 2021, and December 31, 2021. DATA EXTRACTION: Candidate articles were organized by clinical domain based on the emerging themes from all studies. A modified Delphi process was applied to obtain consensus on the most impactful publication within each clinical domain based on overall contribution to scientific knowledge and novelty to the literature. DATA SYNTHESIS: The search revealed 830 articles, of which 766 were excluded leaving 64 candidate articles for the Delphi process. These 64 articles were organized by clinical domain including: emergency/neurology, cardiopulmonary, nephrology/fluids, infectious diseases, metabolic, immunomodulation, and nutrition/gastroenterology. Each domain required the a priori defined three Delphi rounds. The resultant most impactful articles from each domain included five randomized controlled trials and two systematic review/meta-analyses. Topics studied included sedation during mechanical ventilation, anticoagulation in COVID-19, extended infusion beta-lactams, interleukin-6 antagonists in COVID-19, balanced crystalloid resuscitation, vitamin C/thiamine/hydrocortisone in sepsis, and promotility agents during enteral feeding. CONCLUSIONS: This synoptic review provides a summary and perspective of the most impactful articles relevant to the pharmacotherapy of critically ill adults published in 2021.
KW - COVID-19
KW - critical care
KW - drug therapy
KW - pharmacotherapy
KW - review
KW - sepsis
UR - https://www.scopus.com/pages/publications/85144971007
UR - https://www.scopus.com/inward/citedby.url?scp=85144971007&partnerID=8YFLogxK
U2 - 10.1097/CCE.0000000000000823
DO - 10.1097/CCE.0000000000000823
M3 - Review article
AN - SCOPUS:85144971007
SN - 2639-8028
VL - 4
SP - E0823
JO - Critical Care Explorations
JF - Critical Care Explorations
IS - 12
ER -
