Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban; Khaled A. Shaaban; Gerhard Kelter; Heinz Herbert Fiebig; Hartmut Laatsch

doi:10.3390/md19120715

Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Mohamed Shaaban
, Khaled A. Shaaban
, Gerhard Kelter
, Heinz Herbert Fiebig
, Hartmut Laatsch

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

14 Citas (Scopus)

Resumen

Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

Idioma original	English
Número de artículo	715
Publicación	Marine Drugs
Volumen	19
N.º	12
DOI	https://doi.org/10.3390/md19120715
Estado	Published - dic 2021

Nota bibliográfica

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Financiación

Funding: The financial support of this work was funded by a grant from the Bundesministerium für Bildung und Forschung (BMBF, grant 03F0415A).

Financiadores	Número del financiador
Bundesministerium für Bildung und Forschung	03F0415A

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Life below water

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

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10.3390/md19120715

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abstract = "Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E{\textendash}G (1a{\textendash}3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.",

keywords = "Cytotoxicity, Isoquinolinequinones, Mansouramycins, Marine-derived Streptomyces sp",

author = "Mohamed Shaaban and Shaaban, \{Khaled A.\} and Gerhard Kelter and Fiebig, \{Heinz Herbert\} and Hartmut Laatsch",

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doi = "10.3390/md19120715",

language = "English",

volume = "19",

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T1 - Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

AU - Shaaban, Mohamed

AU - Shaaban, Khaled A.

AU - Kelter, Gerhard

AU - Fiebig, Heinz Herbert

AU - Laatsch, Hartmut

PY - 2021/12

Y1 - 2021/12

N2 - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

AB - Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycins A (5) and D (6). Their structures were elucidated by computer-assisted interpretation of 1D and 2D NMR spectra, high-resolution mass spectrometry, and by comparison with related compounds. Cytotoxicity profiling of the mansouramycins in a panel of up to 36 tumor cell lines indicated a significant cytotoxicity and good tumor selectivity for mansouramycin F (2a), while the activity profile of E (1a) was less attractive.

KW - Cytotoxicity

KW - Isoquinolinequinones

KW - Mansouramycins

KW - Marine-derived Streptomyces sp

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U2 - 10.3390/md19120715

DO - 10.3390/md19120715

M3 - Article

C2 - 34940714

AN - SCOPUS:85121605835

SN - 1660-3397

VL - 19

JO - Marine Drugs

JF - Marine Drugs

IS - 12

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ER -

Mansouramycins E–G, cytotoxic isoquinolinequinones from marine streptomycetes

Resumen

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Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

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