Mathematical model of chronic pancreatitis

Wenrui Hao; Hannah M. Komar; Phil A. Hart; Darwin L. Conwell; Gregory B. Lesinski; Avner Friedman

doi:10.1073/pnas.1620264114

Mathematical model of chronic pancreatitis

Wenrui Hao, Hannah M. Komar, Phil A. Hart, Darwin L. Conwell, Gregory B. Lesinski, Avner Friedman

Producción científica: Article › revisión exhaustiva

30 Citas (Scopus)

Resumen

Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-α) and tocilizumab or siltuximab (anti-IL-6/IL-6R).

Idioma original	English
Páginas (desde-hasta)	5011-5016
Número de páginas	6
Publicación	Proceedings of the National Academy of Sciences of the United States of America
Volumen	114
N.º	19
DOI	https://doi.org/10.1073/pnas.1620264114
Estado	Published - may 9 2017

Nota bibliográfica

Funding Information:
W.H. and A.F. have been supported by the Mathematical Biosciences Institute and the National Science Foundation under Grant DMS 0931642. This work was also supported in part through funding from the National Institutes of Health, including Grants 1 R01 CA208253-01 (to G.B.L.), 1 R21 AI124687-01 (to G.B.L.), and 1 U01 DK108327-01 (to D.L.C. and P.A.H.) and a grant from Chi Rho Clin, Inc. (to G.B.L.).

Financiación

W.H. and A.F. have been supported by the Mathematical Biosciences Institute and the National Science Foundation under Grant DMS 0931642. This work was also supported in part through funding from the National Institutes of Health, including Grants 1 R01 CA208253-01 (to G.B.L.), 1 R21 AI124687-01 (to G.B.L.), and 1 U01 DK108327-01 (to D.L.C. and P.A.H.) and a grant from Chi Rho Clin, Inc. (to G.B.L.).

Financiadores	Número del financiador
Chi Rho Clin, Inc.
Mathematical Biosciences Institute
National Science Foundation Arctic Social Science Program	DMS 0931642
National Institutes of Health (NIH)	1 U01 DK108327-01, 1 R21 AI124687-01
National Childhood Cancer Registry – National Cancer Institute	R01CA208253

ASJC Scopus subject areas

General

Acceder al documento

10.1073/pnas.1620264114

Otros archivos y enlaces

Citar esto

@article{b14f6b8d749a4737a9c6125d076e4acb,

title = "Mathematical model of chronic pancreatitis",

abstract = "Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-α) and tocilizumab or siltuximab (anti-IL-6/IL-6R).",

keywords = "Chronic pancreatitis, Drug studies, Mathematical model",

author = "Wenrui Hao and Komar, \{Hannah M.\} and Hart, \{Phil A.\} and Conwell, \{Darwin L.\} and Lesinski, \{Gregory B.\} and Avner Friedman",

note = "Funding Information: W.H. and A.F. have been supported by the Mathematical Biosciences Institute and the National Science Foundation under Grant DMS 0931642. This work was also supported in part through funding from the National Institutes of Health, including Grants 1 R01 CA208253-01 (to G.B.L.), 1 R21 AI124687-01 (to G.B.L.), and 1 U01 DK108327-01 (to D.L.C. and P.A.H.) and a grant from Chi Rho Clin, Inc. (to G.B.L.).",

year = "2017",

month = may,

day = "9",

doi = "10.1073/pnas.1620264114",

language = "English",

volume = "114",

pages = "5011--5016",

number = "19",

}

TY - JOUR

T1 - Mathematical model of chronic pancreatitis

AU - Hao, Wenrui

AU - Komar, Hannah M.

AU - Hart, Phil A.

AU - Conwell, Darwin L.

AU - Lesinski, Gregory B.

AU - Friedman, Avner

N1 - Funding Information: W.H. and A.F. have been supported by the Mathematical Biosciences Institute and the National Science Foundation under Grant DMS 0931642. This work was also supported in part through funding from the National Institutes of Health, including Grants 1 R01 CA208253-01 (to G.B.L.), 1 R21 AI124687-01 (to G.B.L.), and 1 U01 DK108327-01 (to D.L.C. and P.A.H.) and a grant from Chi Rho Clin, Inc. (to G.B.L.).

PY - 2017/5/9

Y1 - 2017/5/9

N2 - Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-α) and tocilizumab or siltuximab (anti-IL-6/IL-6R).

AB - Chronic pancreatitis (CP) is a progressive inflammatory disease of the pancreas, leading to its fibrotic destruction. There are currently no drugs that can stop or slow the progression of the disease. The etiology of the disease is multifactorial, whereas recurrent attacks of acute pancreatitis are thought to precede the development of CP. A better understanding of the pathology of CP is needed to facilitate improved diagnosis and treatment strategies for this disease. The present paper develops a mathematical model of CP based on a dynamic network that includes macrophages, pancreatic stellate cells, and prominent cytokines that are present at high levels in the CP microenvironment. The model is represented by a system of partial differential equations. The model is used to explore in silico potential drugs that could slow the progression of the disease, for example infliximab (anti-TNF-α) and tocilizumab or siltuximab (anti-IL-6/IL-6R).

KW - Chronic pancreatitis

KW - Drug studies

KW - Mathematical model

UR - https://www.scopus.com/pages/publications/85019067777

UR - https://www.scopus.com/inward/citedby.url?scp=85019067777&partnerID=8YFLogxK

U2 - 10.1073/pnas.1620264114

DO - 10.1073/pnas.1620264114

M3 - Article

C2 - 28439020

AN - SCOPUS:85019067777

SN - 0027-8424

VL - 114

SP - 5011

EP - 5016

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 19

ER -

Mathematical model of chronic pancreatitis

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto