Mechanism of Prostaglandin E₂ Stimulation of Renin Secretion

Intrarenal infusion of acetylcholine, bradykinin, eledoisin, and PGE₂ increased renal blood flow to a similar degree. Sodium and potassium excretion were similarly affected by each vasodilator. Renin secretion increased following PGE₂ but was unaffected by acetylcholine, bradykinin, or eledoisin. It is suggested that PGE₂ increases renin secretion by a direct effect on the juxtaglomerular apparatus.