Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

Milan Bera; Atanu Modak; Tuhin Patra; Arun Maji; Debabrata Maiti

doi:10.1021/ol502823c

Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

Milan Bera
, Atanu Modak
, Tuhin Patra
, Arun Maji
, Debabrata Maiti

Pharmaceutical Sciences

Producción científica: Article › revisión exhaustiva

191 Citas (Scopus)

Resumen

A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

Idioma original	English
Páginas (desde-hasta)	5760-5763
Número de páginas	4
Publicación	Organic Letters
Volumen	16
N.º	21
DOI	https://doi.org/10.1021/ol502823c
Estado	Published - nov 7 2014

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Publisher Copyright:
© 2014 American Chemical Society.

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol502823c

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abstract = "A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.",

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AU - Bera, Milan

AU - Modak, Atanu

AU - Patra, Tuhin

AU - Maji, Arun

AU - Maiti, Debabrata

PY - 2014/11/7

Y1 - 2014/11/7

N2 - A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

AB - A nitrile-based template attached with a phenylacetic acid framework promoted meta-selective C-H bond olefination. This palladium-catalyzed protocol is applicable to a wide range of substituted phenylacetic acids and tolerates a variety of functional groups. The versatility of this operationally simple method has been demonstrated through drug diversification.

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UR - https://www.scopus.com/pages/publications/84910011461#tab=citedBy

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JO - Organic Letters

JF - Organic Letters

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Meta -selective arene C-H bond olefination of arylacetic acid using a nitrile-based directing group

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