Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

Shuiqin Wu; Joe Chappell

doi:10.1016/j.copbio.2008.02.007

Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

Shuiqin Wu
, Joe Chappell

Producción científica: Review article › revisión exhaustiva

112 Citas (Scopus)

Resumen

Plant natural products play essential roles in plant survivability and many of them are used as nutrients, colorants, flavors, fragrances, and medicines. Genetic engineering of plants for natural products can help alleviate the demands for limited natural resources. Successes in enhancing production capacities have included manipulating blocks of genes coding for segments of pathways, over-expression of putative rate-limiting steps in pathways, expression of transcription factors regulating the entire metabolic pathways, and the construction of novel branch pathways capable of diverting carbon to the biosynthesis of unique metabolites in unexpected intracellular compartments. Further enhancements are likely if more efficient pathways can be constructed, providing for the efficient channeling of intermediates to final products, and if the means for sequestering natural products in planta can be accomplished.

Idioma original	English
Páginas (desde-hasta)	145-152
Número de páginas	8
Publicación	Current Opinion in Biotechnology
Volumen	19
N.º	2
DOI	https://doi.org/10.1016/j.copbio.2008.02.007
Estado	Published - abr 2008

Nota bibliográfica

Funding Information:
Work from the authors’ laboratory discussed here has been supported by grants from NSF and Firmenich, SA. We thank Drs Jeanne Rasbery and Walter Suza for their critical comments on this manuscript.

Financiación

Work from the authors’ laboratory discussed here has been supported by grants from NSF and Firmenich, SA. We thank Drs Jeanne Rasbery and Walter Suza for their critical comments on this manuscript.

Financiadores
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

Acceder al documento

10.1016/j.copbio.2008.02.007

Otros archivos y enlaces

Citar esto

@article{a38ee62a6e3e4cb59c4153298e09c14d,

title = "Metabolic engineering of natural products in plants; tools of the trade and challenges for the future",

abstract = "Plant natural products play essential roles in plant survivability and many of them are used as nutrients, colorants, flavors, fragrances, and medicines. Genetic engineering of plants for natural products can help alleviate the demands for limited natural resources. Successes in enhancing production capacities have included manipulating blocks of genes coding for segments of pathways, over-expression of putative rate-limiting steps in pathways, expression of transcription factors regulating the entire metabolic pathways, and the construction of novel branch pathways capable of diverting carbon to the biosynthesis of unique metabolites in unexpected intracellular compartments. Further enhancements are likely if more efficient pathways can be constructed, providing for the efficient channeling of intermediates to final products, and if the means for sequestering natural products in planta can be accomplished.",

author = "Shuiqin Wu and Joe Chappell",

note = "Funding Information: Work from the authors{\textquoteright} laboratory discussed here has been supported by grants from NSF and Firmenich, SA. We thank Drs Jeanne Rasbery and Walter Suza for their critical comments on this manuscript. ",

year = "2008",

month = apr,

doi = "10.1016/j.copbio.2008.02.007",

language = "English",

volume = "19",

pages = "145--152",

number = "2",

}

TY - JOUR

T1 - Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

AU - Wu, Shuiqin

AU - Chappell, Joe

N1 - Funding Information: Work from the authors’ laboratory discussed here has been supported by grants from NSF and Firmenich, SA. We thank Drs Jeanne Rasbery and Walter Suza for their critical comments on this manuscript.

PY - 2008/4

Y1 - 2008/4

N2 - Plant natural products play essential roles in plant survivability and many of them are used as nutrients, colorants, flavors, fragrances, and medicines. Genetic engineering of plants for natural products can help alleviate the demands for limited natural resources. Successes in enhancing production capacities have included manipulating blocks of genes coding for segments of pathways, over-expression of putative rate-limiting steps in pathways, expression of transcription factors regulating the entire metabolic pathways, and the construction of novel branch pathways capable of diverting carbon to the biosynthesis of unique metabolites in unexpected intracellular compartments. Further enhancements are likely if more efficient pathways can be constructed, providing for the efficient channeling of intermediates to final products, and if the means for sequestering natural products in planta can be accomplished.

AB - Plant natural products play essential roles in plant survivability and many of them are used as nutrients, colorants, flavors, fragrances, and medicines. Genetic engineering of plants for natural products can help alleviate the demands for limited natural resources. Successes in enhancing production capacities have included manipulating blocks of genes coding for segments of pathways, over-expression of putative rate-limiting steps in pathways, expression of transcription factors regulating the entire metabolic pathways, and the construction of novel branch pathways capable of diverting carbon to the biosynthesis of unique metabolites in unexpected intracellular compartments. Further enhancements are likely if more efficient pathways can be constructed, providing for the efficient channeling of intermediates to final products, and if the means for sequestering natural products in planta can be accomplished.

UR - https://www.scopus.com/pages/publications/42249110346

UR - https://www.scopus.com/pages/publications/42249110346#tab=citedBy

U2 - 10.1016/j.copbio.2008.02.007

DO - 10.1016/j.copbio.2008.02.007

M3 - Review article

C2 - 18375112

AN - SCOPUS:42249110346

SN - 0958-1669

VL - 19

SP - 145

EP - 152

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 2

ER -

Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto