Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

William F. Maragos; Rebekah Jakel; Dathan Chesnut; Chava B. Pocernich; D. Allan Butterfield; Daret St Clair; Wayne A. Cass

doi:10.1016/S0006-8993(00)02707-4

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

William F. Maragos
, Rebekah Jakel
, Dathan Chesnut
, Chava B. Pocernich
, D. Allan Butterfield
, Daret St Clair
, Wayne A. Cass

Producción científica: Article › revisión exhaustiva

48 Citas (Scopus)

Resumen

We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

Idioma original	English
Páginas (desde-hasta)	218-222
Número de páginas	5
Publicación	Brain Research
Volumen	878
N.º	1-2
DOI	https://doi.org/10.1016/S0006-8993(00)02707-4
Estado	Published - sept 29 2000

Nota bibliográfica

Funding Information:
This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

Financiación

This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

Financiadores	Número del financiador
National Institute on Drug Abuse	R29DA010115
U.S. Public Health Service	CA 59835, AG 10836, NS 01941

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02707-4

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title = "Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase",

abstract = "We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.",

keywords = "Dopamine, Manganese superoxide dismutase, Methamphetamine, Oxidative stress, Striatum, Transgenic mouse",

author = "Maragos, \{William F.\} and Rebekah Jakel and Dathan Chesnut and Pocernich, \{Chava B.\} and Butterfield, \{D. Allan\} and \{St Clair\}, Daret and Cass, \{Wayne A.\}",

note = "Funding Information: This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky{\textquoteright}s Image Facility with the assistance of Ms. Mary Gail Engle.",

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month = sep,

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doi = "10.1016/S0006-8993(00)02707-4",

language = "English",

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T1 - Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

AU - Maragos, William F.

AU - Jakel, Rebekah

AU - Chesnut, Dathan

AU - Pocernich, Chava B.

AU - Butterfield, D. Allan

AU - St Clair, Daret

AU - Cass, Wayne A.

N1 - Funding Information: This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

PY - 2000/9/29

Y1 - 2000/9/29

N2 - We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

AB - We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

KW - Dopamine

KW - Manganese superoxide dismutase

KW - Methamphetamine

KW - Oxidative stress

KW - Striatum

KW - Transgenic mouse

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UR - https://www.scopus.com/pages/publications/0034730446#tab=citedBy

U2 - 10.1016/S0006-8993(00)02707-4

DO - 10.1016/S0006-8993(00)02707-4

M3 - Article

C2 - 10996156

AN - SCOPUS:0034730446

SN - 0006-8993

VL - 878

SP - 218

EP - 222

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

Acceder al documento

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