Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

C. A. Kassed; T. L. Butler; M. T. Navidomskis; M. N. Gordon; D. Morgan; K. R. Pennypacker

doi:10.1016/S0169-328X(02)00658-7

Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

C. A. Kassed
, T. L. Butler
, M. T. Navidomskis
, M. N. Gordon
, D. Morgan
, K. R. Pennypacker

Producción científica: Article › revisión exhaustiva

24 Citas (Scopus)

Resumen

Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

Idioma original	English
Páginas (desde-hasta)	152-157
Número de páginas	6
Publicación	Molecular Brain Research
Volumen	110
N.º	1
DOI	https://doi.org/10.1016/S0169-328X(02)00658-7
Estado	Published - ene 31 2003

Nota bibliográfica

Funding Information:
This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.).

Financiación

This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.).

Financiadores	Número del financiador
National Institutes of Health (NIH)	RO1 NS39141-01A2
National Institute of Neurological Disorders and Stroke	R01NS039141
American Heart Association	0120233B, 9930072N

ODS de las Naciones Unidas

Este resultado contribuye a los siguientes Objetivos de Desarrollo Sostenible

Good health and well being

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Acceder al documento

10.1016/S0169-328X(02)00658-7

Otros archivos y enlaces

Citar esto

@article{2cb1320e2a4142bd8e3a759ab218da16,

title = "Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury",

abstract = "Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.",

keywords = "Fluoro-Jade, Hippocampus, NF-κB, Neurodegeneration, Neuroprotection, Neurotoxicity, P50, Presenilin-1 gene mutations, Resistance to injury, Signal transduction, Transcription factors, Trimethyltin, mutPS-1 mice",

author = "Kassed, \{C. A.\} and Butler, \{T. L.\} and Navidomskis, \{M. T.\} and Gordon, \{M. N.\} and D. Morgan and Pennypacker, \{K. R.\}",

note = "Funding Information: This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.). ",

year = "2003",

month = jan,

day = "31",

doi = "10.1016/S0169-328X(02)00658-7",

language = "English",

volume = "110",

pages = "152--157",

number = "1",

}

TY - JOUR

T1 - Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

AU - Kassed, C. A.

AU - Butler, T. L.

AU - Navidomskis, M. T.

AU - Gordon, M. N.

AU - Morgan, D.

AU - Pennypacker, K. R.

N1 - Funding Information: This research was supported by NIH Grant RO1 NS39141-01A2 and American Heart Association Grants 9930072N (K.R.P.) and 0120233B (T.L.B.).

PY - 2003/1/31

Y1 - 2003/1/31

N2 - Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

AB - Mutations in the presenilin-1 (mutPS-1) gene, a cause of familial Alzheimer's disease, increase the susceptibility of neurons to apoptotic death. Using the trimethyltin model of hippocampal neurodegeneration, mice expressing the human mutPS-1 gene (M146L) exhibited increased neurodegeneration and mortality relative to non-transgenic littermates. Activation of NF-κB p50 was found to be impaired in transgenic mice with unaltered expression levels suggesting that mutPS-1 expression inhibits p50 activation to adversely affect neuronal resistance to injury.

KW - Fluoro-Jade

KW - Hippocampus

KW - NF-κB

KW - Neurodegeneration

KW - Neuroprotection

KW - Neurotoxicity

KW - P50

KW - Presenilin-1 gene mutations

KW - Resistance to injury

KW - Signal transduction

KW - Transcription factors

KW - Trimethyltin

KW - mutPS-1 mice

UR - https://www.scopus.com/pages/publications/0037474096

UR - https://www.scopus.com/pages/publications/0037474096#tab=citedBy

U2 - 10.1016/S0169-328X(02)00658-7

DO - 10.1016/S0169-328X(02)00658-7

M3 - Article

C2 - 12573544

AN - SCOPUS:0037474096

SN - 0169-328X

VL - 110

SP - 152

EP - 157

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 1

ER -

Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury

Resumen

Nota bibliográfica

Financiación

ODS de las Naciones Unidas

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto