TY - JOUR
T1 - Mitochondrial and nuclear p53 localization in cardiomyocytes
T2 - Redox modulation by doxorubicin (Adriamycin)?
AU - Nithipongvanitch, Ramaneeya
AU - Ittarat, Wanida
AU - Cole, Marsha P.
AU - Tangpong, Jitbanjong
AU - St. Clair, Daret K.
AU - Oberley, Terry D.
PY - 2007/7
Y1 - 2007/7
N2 - Reactive oxygen (ROS) and nitrogen species (RNS) generation have been proposed to be an important mechanism of doxorubicin (Adriamycin; ADR)-induced cardiotoxicity and cardiomyocyte apoptosis, processes that may be mediated by p53 protein. We note that ADR treatment resulted in increased levels of p53 protein in cardiomyocyte mitochondria and nuclei. Modulation of the cardiomyocyte redox state in genetically engineered mice by modulation of enzymes involved in metabolism of ROS/RNS, manganese superoxide dismutase (MnSOD), or inducible nitric oxide synthase (iNOS), or a combination of these, regulated levels of mitochondrial/nuclear p53 in cardiomyocytes after ADR administration. These observations led to the hypothesis that mitochondrial/nuclear p53 localization and function in the cardiomyocyte response to ADR may be regulated through redox-dependent mechanism(s).
AB - Reactive oxygen (ROS) and nitrogen species (RNS) generation have been proposed to be an important mechanism of doxorubicin (Adriamycin; ADR)-induced cardiotoxicity and cardiomyocyte apoptosis, processes that may be mediated by p53 protein. We note that ADR treatment resulted in increased levels of p53 protein in cardiomyocyte mitochondria and nuclei. Modulation of the cardiomyocyte redox state in genetically engineered mice by modulation of enzymes involved in metabolism of ROS/RNS, manganese superoxide dismutase (MnSOD), or inducible nitric oxide synthase (iNOS), or a combination of these, regulated levels of mitochondrial/nuclear p53 in cardiomyocytes after ADR administration. These observations led to the hypothesis that mitochondrial/nuclear p53 localization and function in the cardiomyocyte response to ADR may be regulated through redox-dependent mechanism(s).
UR - https://www.scopus.com/pages/publications/34250375254
UR - https://www.scopus.com/pages/publications/34250375254#tab=citedBy
U2 - 10.1089/ars.2007.1632
DO - 10.1089/ars.2007.1632
M3 - Review article
C2 - 17508921
AN - SCOPUS:34250375254
SN - 1523-0864
VL - 9
SP - 1001
EP - 1008
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 7
ER -