Morphologic alterations of chohnergic processes in the neocortex of aged rats

David M. Armstrong; Louis B. Hersh; Fred H. Gage

doi:10.1016/S0197-4580(88)80051-4

Morphologic alterations of chohnergic processes in the neocortex of aged rats

David M. Armstrong
, Louis B. Hersh
, Fred H. Gage

Producción científica: Article › revisión exhaustiva

30 Citas (Scopus)

Resumen

In the present study we observed enlarged cholinergic processes in the neocortex of aged Fischer 344 rats. These swollen ChAT-positive profiles appeared either as a single axon enlargement or, in many instances, the bulbous processes coalesced to form grape-like clusters of immunoreactivity. The latter structures looked similar to the immunoreactive profiles observed in the cortex of patients with Alzheimer's disease and in the rat septum following fimbria-fornix transection. Together, these data provide evidence that morphologic changes occur within processes of cholinergic neurons in the aged rat. Moreover, the similarity in appearance between the axonal alterations in the aged rat and in patients with Alzheimer's disease suggests a common pathologic process.

Idioma original	English
Páginas (desde-hasta)	199-205
Número de páginas	7
Publicación	Neurobiology of Aging
Volumen	9
N.º	C
DOI	https://doi.org/10.1016/S0197-4580(88)80051-4
Estado	Published - 1988

Nota bibliográfica

Funding Information:
This work was supported by NIH Grants AG05893, AG05344, AG05386 and AG06088 and grants from the Office of Naval Research, the Margaret and Herbert Hoover Foundation, and the State of California Department of Health Services, Alzheimer's Disease Program and the John Douglas French Foundation. We also thank Ms. Roxanne Sheffield for her invaluable technical assistance.

Financiación

This work was supported by NIH Grants AG05893, AG05344, AG05386 and AG06088 and grants from the Office of Naval Research, the Margaret and Herbert Hoover Foundation, and the State of California Department of Health Services, Alzheimer's Disease Program and the John Douglas French Foundation. We also thank Ms. Roxanne Sheffield for her invaluable technical assistance.

Financiadores	Número del financiador
John Douglas French Alzheimer's Foundation
State of California Department of Health Services
National Institutes of Health (NIH)	AG05344, AG05386, AG06088
Office of Naval Research
National Institute on Aging	R01AG005893
Herbert W. Hoover Foundation

ASJC Scopus subject areas

General Neuroscience
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/S0197-4580(88)80051-4

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title = "Morphologic alterations of chohnergic processes in the neocortex of aged rats",

abstract = "In the present study we observed enlarged cholinergic processes in the neocortex of aged Fischer 344 rats. These swollen ChAT-positive profiles appeared either as a single axon enlargement or, in many instances, the bulbous processes coalesced to form grape-like clusters of immunoreactivity. The latter structures looked similar to the immunoreactive profiles observed in the cortex of patients with Alzheimer's disease and in the rat septum following fimbria-fornix transection. Together, these data provide evidence that morphologic changes occur within processes of cholinergic neurons in the aged rat. Moreover, the similarity in appearance between the axonal alterations in the aged rat and in patients with Alzheimer's disease suggests a common pathologic process.",

keywords = "Aged rat, Alzheimer's disease, Choline acetyltransferase, Immunocytochemistry, Neuritic plaques",

author = "Armstrong, \{David M.\} and Hersh, \{Louis B.\} and Gage, \{Fred H.\}",

note = "Funding Information: This work was supported by NIH Grants AG05893, AG05344, AG05386 and AG06088 and grants from the Office of Naval Research, the Margaret and Herbert Hoover Foundation, and the State of California Department of Health Services, Alzheimer's Disease Program and the John Douglas French Foundation. We also thank Ms. Roxanne Sheffield for her invaluable technical assistance.",

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doi = "10.1016/S0197-4580(88)80051-4",

language = "English",

volume = "9",

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AU - Armstrong, David M.

AU - Hersh, Louis B.

AU - Gage, Fred H.

N1 - Funding Information: This work was supported by NIH Grants AG05893, AG05344, AG05386 and AG06088 and grants from the Office of Naval Research, the Margaret and Herbert Hoover Foundation, and the State of California Department of Health Services, Alzheimer's Disease Program and the John Douglas French Foundation. We also thank Ms. Roxanne Sheffield for her invaluable technical assistance.

PY - 1988

Y1 - 1988

N2 - In the present study we observed enlarged cholinergic processes in the neocortex of aged Fischer 344 rats. These swollen ChAT-positive profiles appeared either as a single axon enlargement or, in many instances, the bulbous processes coalesced to form grape-like clusters of immunoreactivity. The latter structures looked similar to the immunoreactive profiles observed in the cortex of patients with Alzheimer's disease and in the rat septum following fimbria-fornix transection. Together, these data provide evidence that morphologic changes occur within processes of cholinergic neurons in the aged rat. Moreover, the similarity in appearance between the axonal alterations in the aged rat and in patients with Alzheimer's disease suggests a common pathologic process.

AB - In the present study we observed enlarged cholinergic processes in the neocortex of aged Fischer 344 rats. These swollen ChAT-positive profiles appeared either as a single axon enlargement or, in many instances, the bulbous processes coalesced to form grape-like clusters of immunoreactivity. The latter structures looked similar to the immunoreactive profiles observed in the cortex of patients with Alzheimer's disease and in the rat septum following fimbria-fornix transection. Together, these data provide evidence that morphologic changes occur within processes of cholinergic neurons in the aged rat. Moreover, the similarity in appearance between the axonal alterations in the aged rat and in patients with Alzheimer's disease suggests a common pathologic process.

KW - Aged rat

KW - Alzheimer's disease

KW - Choline acetyltransferase

KW - Immunocytochemistry

KW - Neuritic plaques

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UR - https://www.scopus.com/pages/publications/0024158565#tab=citedBy

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DO - 10.1016/S0197-4580(88)80051-4

M3 - Article

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AN - SCOPUS:0024158565

SN - 0197-4580

VL - 9

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JO - Neurobiology of Aging

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Morphologic alterations of chohnergic processes in the neocortex of aged rats

Resumen

Nota bibliográfica

Financiación

ASJC Scopus subject areas

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