TY - GEN
T1 - Multigrid finite volume method for FGF-2 transport and binding
AU - Shen, Wensheng
AU - Forsten-Williams, Kimberly
AU - Fannon, Michael
AU - Zhang, Changjiang
AU - Zhang, Jun
PY - 2010
Y1 - 2010
N2 - A multigrid finite volume method has been developed to accelerate the solution process for simulating complex biological transport phenomena, involving convection, diffusion, and reaction. The method has been applied to a computational model which includes media flow in a cell-lined cylindrical vessel and fibroblast growth factor-2 (FGF-2) within the fluid capable of binding to receptors and heparan sulfate proteoglycans (HSPGs) on the cell surface. The differential equations were discretized by the finite volume method and solved with the multigrid V-cycle algorithm. Our work indicates that the multigrid finite volume method may allow users to investigate complex biological systems with less CPU time.
AB - A multigrid finite volume method has been developed to accelerate the solution process for simulating complex biological transport phenomena, involving convection, diffusion, and reaction. The method has been applied to a computational model which includes media flow in a cell-lined cylindrical vessel and fibroblast growth factor-2 (FGF-2) within the fluid capable of binding to receptors and heparan sulfate proteoglycans (HSPGs) on the cell surface. The differential equations were discretized by the finite volume method and solved with the multigrid V-cycle algorithm. Our work indicates that the multigrid finite volume method may allow users to investigate complex biological systems with less CPU time.
KW - Biological transport
KW - FGF-2
KW - Finite volume
KW - Multigrid
KW - Navier-Stokes
UR - https://www.scopus.com/pages/publications/78651577938
UR - https://www.scopus.com/pages/publications/78651577938#tab=citedBy
U2 - 10.1007/978-90-481-9419-3_23
DO - 10.1007/978-90-481-9419-3_23
M3 - Conference contribution
AN - SCOPUS:78651577938
SN - 9789048194186
T3 - Lecture Notes in Electrical Engineering
SP - 297
EP - 310
BT - Machine Learning and Systems Engineering
T2 - International Conference on Advances in Machine Learning and Systems Engineering
Y2 - 20 October 2009 through 22 October 2009
ER -